Study on the Aggregation and Deaggregation Behaviors of Phosphatidylcholines  

作　　者：计国桢 龙亚秋 蒋锡夔 

机构地区：[1]Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2003年第7期731-738,共8页中国化学（英文版）

基　　金：National Natural Science Foundation of China(No.29392201).

摘　　要：Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (Ln) and their analogues 1, 2-diacyI-sn-glycerol-3-phosphoric add bro-moethyl ester (Pn), have been investigated in MeOH-H2O binary systems of different volume fractions (designated as Φ) of the organic component, by employing a-nephthylethyl lauryl ether (Np-12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i.e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deag-gregation are also discussed.Phosphatidylcholines and their analogs, the functional building block of the membrane, are recently found to mediate multiple physiological processes and exhibit a broad range of desirable pharmacological effects, which involve hydrophobic lipophilic interactions (HLI) between the phospholipid and the cell membrane. The HLI behavior of phosphatidylcholines (Ln) and their analogues 1, 2-diacyI-sn-glycerol-3-phosphoric add bro-moethyl ester (Pn), have been investigated in MeOH-H2O binary systems of different volume fractions (designated as Φ) of the organic component, by employing a-nephthylethyl lauryl ether (Np-12) as fluorescent probe. A very interesting observation is that the Ln possesses double character, i.e., it behaves both as an aggregator and as a deaggregator. The effects of the structure and the environment on the coaggregation and deag-gregation are also discussed.

关 键 词：PHOSPHATIDYLCHOLINE hydrophobic lipophilic interac-tions (HLI) AGGREGATION DEAGGREGATION 

分 类 号：O627.51[理学—有机化学]