Alkylation of Sulfur Ligand in Cysteinate-Iron Chelates by a 1,2,4,5-Tetraoxane  

作　　者：刘鹤华 伍贻康 沈鑫 

机构地区：[1]State Key Laboratory of Bioorganic & Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences,Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2003年第7期875-877,共3页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation(Nos.20025207,20272071,29832020),the Qinghaosu Science and Technology Foundation,Chinese Academy of Sciences(No.KGCX2-SW-209)and the Major State Basic Research Development Program(No.G2000077502

摘　　要：Reaction of a 1,2,4,5-tetraoxane with cysteinate-iron in the presence of excess methyl cysteinate led to formation of sulfur-alkylated methyl cysteinate in 33% yield, illustrating a possible mechanism for tetraoxanes' antimalarial action.Reaction of a 1,2,4,5-tetraoxane with cysteinate-iron in the presence of excess methyl cysteinate led to formation of sulfur-alkylated methyl cysteinate in 33% yield, illustrating a possible mechanism for tetraoxanes' antimalarial action.

关 键 词：ANTIMALARIAL ARTEMISININ tetraoxanes free radicals alkylation 

分 类 号：O641.4[理学—物理化学]