禽类基因工程重组干扰素研究进展  

The Progress of Study on Avian Recombinant Interferon

作　　者：夏春[1] 吴丹[1] 阮小飞[1] 

机构地区：[1]中国农业大学动物医学院,北京100094

出　　处：《动物医学进展》2003年第4期39-41,共3页Progress In Veterinary Medicine

基　　金：国家 8 63计划基金资助项目 ( 2 0 0 1AA2 490 3 2 );国家农业生物技术重点实验室开放课题 ( 9910 0 4- 3 )资助项目

摘　　要：近年来 ,多种禽类干扰素基因已被克隆和在大肠杆菌中表达。禽类基因工程重组干扰素在抗马立克病毒、劳斯肉瘤病毒、新城疫病毒、传染性法氏囊病病毒、传染性支气管炎病毒和禽流感病毒方面效果显著 ,展现出了广阔的应用前景。During the last decade, a variety of interferon(IFN) genes have been cloned from many avian species,and IFN genes have been described and expressed in E.Coli. The antiviral activity of recombinant chicken IFN have been studied in Marek's disease(MDV), Rous sarcoma virus(RSV), Newcastle disease virus (NDV), Infectious bursal disease virus (IBDV), Infectious bronchitis virus(IBV), and avian influenza virus(AIV). The present studies demonstrated that recombinant chicken IFN have strong anti-viral activity, implying their potential use in treatment of virus infection in avian.

关 键 词：禽类 基因工程 基因重组 干扰素 大肠杆菌 基因表达 

分 类 号：S814.8[农业科学—畜牧学]