姐妹同患染色体核型异常合并卵巢无性细胞瘤-治疗及随访报道  

Abnormal Karyotype and Dysgerminoma in Two Sisters-treatment and follow up.

作　　者：李东红[1] 杨华光[1] 黄飞[1] 

机构地区：[1]第四军医大学唐都医院妇产科,西安710038

出　　处：《中国优生与遗传杂志》2003年第3期57-57,99,共2页Chinese Journal of Birth Health & Heredity

摘　　要：本文报道同胞姐妹二人同为两性畸形并发性腺无性细胞瘤。其父母非近亲结婚 ,染色体核型均正常。瘤组织病理检查及免疫组织化学检查为单纯无性细胞瘤。妹妹单纯切除病变性腺 ,术后 3年发生远处转移 ,放疗后治愈 ;姐姐接受卵巢癌根治术后化疗一次 ,随访 6年未复发。Two young sisters complicated with hermaphroditism and sexual gland dysgerminoma were reported. Their parents, whose karyotype were normal, married without genetic relationship. Pathological and Immunohistochemical examination of tumor samples from these two sisters showed that the identity of tumor was simple dysgerminoma. Younger sister received simlpe ovariotomy and chemotherapy. Remote metastasis was found 3 years after the first operation and cured by radiotherapy. The older sister received radical operation and preventive chemotherapy. She is well being after 6 year follow up.

关 键 词：两性畸形 卵巢 无性细胞瘤 

分 类 号：R737.31[医药卫生—肿瘤]