KcsA一种新型的K离子通道  

KcsA:A Novel Potassium Ion Channel

作　　者：秦桢[1] 洪剑明[1] 黄勤妮[1] 

机构地区：[1]首都师范大学生物系,北京100037

出　　处：《首都师范大学学报（自然科学版）》2003年第3期57-61,共5页Journal of Capital Normal University：Natural Science Edition

摘　　要：DeclanADoyleetal于 1998年利用X射线结晶分析在Streptomyceslividans(变铅青链霉菌 )中发现的KcsA(K+conductionandselectivityarchitecture)是一种新型的K+ 通道 .它由四个亚基组成 ,每个亚基含有两个α 螺旋 ,在KcsA的中央有一个选择性滤膜 ,对K+ 具有特殊的通透性 .本文仅对KcsA的结构及其对K+ 选择性介导的作用机制进行综述 .KcsA(K+ conduction and selectivity architecture)is a novel potassium channel which was discovered by Declan A.Doyle et al with X-ray crystallize analysis in Streptomyces lividans in 1998.KcsA consists of four subunit and each subunit consists of two alpha-helix.There is a selective filter membrane at the middle of KcsA,which has a special permeation for potassium ion.The structure of KcsA and the possible mechanism of KcsA is discussed in the review.

关 键 词：KCSA K离子通道 K^+通道 变铅青链霉菌 Α-螺旋 选择性滤膜 作用机制 孔道结构 氨基酸序列 

分 类 号：Q73[生物学—分子生物学]