原花青素的研究进展  

Progress in Procyanidins Research

作　　者：张慧文[1,2] 张玉[1] 马超美[1] 

机构地区：[1]内蒙古大学生命科学学院,内蒙古呼和浩特010021 [2]包头医学院,内蒙古包头014040

出　　处：《食品科学》2015年第5期296-304,共9页Food Science

摘　　要：原花青素是一类广泛存在于自然界中的黄烷-3-醇类化合物。本文详细整理国内外有关原花青素的报道,就其化学结构、生物活性、吸收代谢和毒理学特性做详细综述。其中,原花青素的化学结构根据其聚合度分类,结合结构单元、连接方式、空间构型和取代基的不同,并配结构图列举说明每种类型;原花青素有很强的生物活性,如抗氧化活性、防治心血管疾病、抗癌、抗高血压、降血脂、降血糖等;原花青素的吸收代谢包括体外Caco-2细胞模型和体内代谢的研究;毒理学研究表明原花青素的安全性很高。本文结合国内外的最新文献,较为全面地介绍生物活性强、食源性和低毒性的原花青素类成分,为该类成分的进一步研究提供参考。Procyanidins,also known as condensed tannins,are naturally occurring flavan-3-ols,present widely in the plant kingdom.This review compiles the recent reports on the chemical composition,biological activities,absorption,metabolism and toxicology of procyanidins in China and abroad.The chemical structures of procyanidins are classified according to polymerization degree combined with structure units,connection mode,configuration and substituents,with figures to illustrate each type.This paper summarizes the current knowledge on biological activities,such as antioxidant activity,cardiovascular disease prevention and inhibition of cancer,hypertension,hyperlipidemia,diabetes,etc.Meanwhile,this review elucidates the absorption and metabolism of procyanidins,including Caco-2 cell model and in vivo metabolic studies.At last,toxicological studies show that procyanidins are safe.Based on the latest studies worldwide,procyanidins are considered as natural food-derived antioxidants with strong antioxidant activity and low toxicity.

关 键 词：原花青素 化学结构 生物活性 吸收 代谢 毒理学 

分 类 号：TQ28[化学工程—有机化工]