含烟酸高分子药物微球的合成研究  

Synthesis and characterization of polymeric microspheres containing nicotinic acid

作　　者：孙玉[1] 李庆海[1] 汪凌云[1] 沈良骏[1] 

机构地区：[1]安徽师范大学化学与材料科学学院,安徽芜湖241000

出　　处：《中国药物化学杂志》2003年第5期273-275,共3页Chinese Journal of Medicinal Chemistry

基　　金：国家自然科学基金项目(29773001);安徽省教育厅科研基金项目(2002KJ119)

摘　　要：目的合成可提高药物吸收度的含烟酸的高分子纳米微球。方法通过DCC法和酰氯法将降血脂药物烟酸以酯键连接到甲基丙烯酸-2-羟基乙酯上得到不饱和的含烟酸的单体(MP)化合物,在此基础上用乳液聚合法制备含烟酸的纳米级高分子微球。结果单体和聚合物的结构均经核磁共振谱确定,微球的粒径及表观形态用透射电子显微镜观测。结论乳液聚合法是合成含烟酸高分子药物微球的一种行之有效的方法。Aim To synthesize high medicine-absorbance polymeric nano-microspheres containing nicotinic acid. Method The unsaturated monomer MP was synthesized through the reaction of nicotinic acid and methacrylic acid-2-hydroxyethyl ester by using two different methods(DCC or acyl chloride). Then the nano-microspheres were made from the above compound monomer by using emulsion polymerization. Result The monomer MP and its polymer were characterized by H-NMR. The size and hydrodynamic radius distribution of the nano-microspheres were measured by the transmission electron microscope. Conclusion Polymeric microspheres that contain nicotinic acid can be effectively synthesized by using emulsion polymerization.

关 键 词：药物化学 制备 化学合成 烟酸 乳液聚合 纳米微球 

分 类 号：R914[医药卫生—药物化学]