表皮生长因子受体家族EGFR、c-erbB-2和c-erbB-3蛋白表达与大肠肿瘤不同组织类型的关系  

Relevance of expressions of epidermal growth factor receptor, c-erbB-2, c-erbB-3 in different histological types of colorectal tumors

作　　者：冯莉[1] 吴云林[2] 罗志谋[1] 李惠芳[1] 付极[1] 翟祖康[2] 

机构地区：[1]上海瑞金医院集团闵行医院病理科,201100 [2]上海第二医科大学附属瑞金医院消化科

出　　处：《上海医学》2003年第8期571-573,T001,共4页Shanghai Medical Journal

基　　金：上海市科委科研基金资助项目

摘　　要：目的　探讨表皮生长因子受体 (EGFR)家族EGFR、c erbB 2和c erbB 3蛋白的表达在大肠良、恶性肿瘤不同组织类型中的表达情况。方法　选取病理检查证实的大肠息肉、大肠腺瘤和大肠腺癌患者共 15 1例 ,采用免疫组化Envision技术 ,分别对所选取的标本进行EGFR、c erbB 2和c erbB 3检测 ,对其表达阳性率进行统计学分析。结果　增生性息肉组EGFR、c erbB 2和c erbB 3的阳性表达率均较低 ,分别为 4 2 .86 %、2 1.4 3%和 16 .6 7%。EGFR在管状腺瘤及管状绒毛状腺瘤中的阳性表达率均较高 ,在管状腺瘤中更高 (P <0 .0 5 ) ;c erbB 2在管状腺瘤中的阳性表达率较管状绒毛状腺瘤高 (P <0 .0 5 ) ;c erbB 3在管状绒毛状腺瘤中的阳性表达率较管状腺瘤高 (P <0 .0 5 )。EGFR、c erbB 2和c erbB 3在管状腺癌、乳头状腺癌和黏液腺癌中的阳性表达率均较高 (≥ 5 0 % ) ,差异无显著性 (P >0 .0 5 )。EGFR和c erbB 2在管状腺瘤中的表达率高于管状腺癌 (P<0 .0 5 ) ,c erbB 3在两者中表达的差异无显著性 (P >0 .0 5 )。结论　EGFR、c erbB 2和c erbB 3蛋白表达与大肠增生性息肉无关 ;而在不同的腺瘤和腺癌中 ,EGFR家族蛋白表达的不同可能是由不同类型腺瘤向腺癌转化发生的比率差异导致的 ,此现象有助于解释EGFR家族蛋白在大肠?Objective To appraise the relevance of expressions of epidermal growth factor receptor(EGFR) c erbB 2, c erbB 3 in different histological types of colorectal tumors. Methods The expressions of EGFR, c erbB 2 and c erbB 3 were detected immunohistochemically in 151 colorectal polyps, adenoma and adenocarcinoma diagnosed endoscopically and pathologically, and the results were analyzed statistically. Results The expressions of EGFR, c erbB 2 and c erbB 3 in colorectal tubulovillous adenoma and adenocarcinoma were higher than those in the proliferative polyps. The expression of EGFR was higher in both tubular adenoma and tubulovillous adenoma, but even higher in the formar; c erbB 2 was higher in tubular adenoma than that in tubulovillous while the expression of c erbB 3 was just the contrary( P <0.05). The expressions of EGFR, c erbB 2 and c erbB 3 were high(≥50%) in all types of adenoma and adenocarcinomas( P >0.05). Whereas the expressions of EGFR and c erbB 2 were higher in adenomas than those in adenocarcinomas( P <0.05); and the expression of c erbB 3 in those two types were of no significant difference( P >0.05).Conclusion The expressions of EGFR, c erbB 2 and c erbB 3 have no significient relevance with proliferative polyps, but being different in adenoma and adenocarcinoma. This may be the reason for the proportional difference of different histological types of adenoma progressing to the development of adenocarcinoma, and this may be of help to explain the role of EGFR protein family in the formation of colorectal cancer.

关 键 词：大肠肿瘤 表皮生长因子受体 EGFR C-ERBB-2 c-erbB-3 基因表达 

分 类 号：R735.34[医药卫生—肿瘤]