肝硬化患者β-胡萝卜素的变化及意义  

Determination of plasma β-carotene in patients with liver cirrhosis and its significance

作　　者：陆新良[1] 宋燕华[2] 周君富 钱可大[1] 杜勤[1] 

机构地区：[1]浙江大学医学院附属第二医院消化科,杭州310009 [2]浙江省疾病预防控制中心 [3]浙江省药物滥用监测站

出　　处：《中华消化杂志》2003年第10期607-609,共3页Chinese Journal of Digestion

摘　　要：目的　探讨肝硬化患者血浆 β 胡萝卜素 (P β CAR)含量及其临床意义。 方法　测定 6 3例肝硬化患者和 6 3例年龄及性别配对的正常人P β CAR和血浆过氧化脂质 (P LPO)、红细胞超氧化物歧化酶 (E SOD)、红细胞过氧化脂质 (E LPO)和血清C 反应蛋白 (CRP)的含量 ,并对肝硬化患者的多个因素进行Pearson相关和多元线性回归统计分析。结果　与正常对照组比较 ,肝硬化组P β CAR和E SOD含量明显降低 (P值均 <0 .0 1) ,而P LPO、E LPO和CRP含量明显升高 (P值均 <0 .0 1)。在血吸虫病性肝纤维化、肝炎后肝硬化和酒精性肝硬化中P β CAR和E SOD依次降低 ,而P LPO、E LPO和CRP依次升高 ,三组间差异有显著性 (P值均 <0 .0 1)。相关分析提示肝硬化患者P β CAR与年龄、E SOD、P LPO、E LPO和CRP含量相关 (P值均 <0 .0 1) ,而与患者Child Pugh积分无关 (P >0 .0 5 )。进一步的多元线性回归分析提示肝硬化患者P β CAR含量与E SOD和CRP的关系最密切。 结论　肝硬化患者P β CAR含量显著下降 ,与肝硬化病因和体内氧化抗氧化系统密切相关。Objective To explore the change of β-carotene in patients with liver cirrhosis and its clinical significance. Methods The plasma levels of β-carotene (P-β-CAR), lipoperoxides (P-LPO), C-reactive protein (CRP) and the activities of erythrocyte superoxide dismutase (E-SOD) and lipoperoxides (E-LPO) in 63 patients with liver cirrhosis were measured, using sex-and age-matched subjects from 63 healthy people as the control group. Linear regression and Pearson correlation were performed among the factors in cirrhosis patients. Results Compared with the control group, the levels of P-β-CAR and E-SOD were significantly decreased in the liver cirrhosis group (all P <0.01), and the levels of P-LPO, E-LPO and CRP were significantly increased in liver cirrhosis group (all P <0.01). The levels of P-β-CAR and E-SOD were gradually decreased in the schistosomal hepatic fibrosis group, posthepatic cirrhosis group and alcoholic cirrhosis group (all P <0.01). While the levels of P-LPO, E-LPO and CRP were progressively increased for the same groups (all P <0.01). Correlation analysis showed that there were linear correlations between the P-β-CAR contents and the age, E-SOD, P-LPO, E-LPO and CRP levels (all P <0.01). There was no relationship between the P-β-CAR contents and the Child-Pugh score ( P >0.05). The stepwise regression showed that the P-β-CAR contents correlated most closely to E-SOD and CRP levels. Conclusion The levels of β-carotene decreased significantly, and correlated with the etiologic factors of cirrhosis, oxidation and antioxidation in the patients with liver cirrhosis.

关 键 词：肝硬化 Β-胡萝卜素 C-反应蛋白 血浆过氧化脂质 

分 类 号：R575.2[医药卫生—消化系统]