E-钙粘素与大肠癌侵润转移的关系  

Relationship of expression of E - cadherin to invasion and metastasis of colorectal cancer

作　　者：陶雅军[1] 任欣[1] 邓兆滨[2] 

机构地区：[1]大连大学医学院,辽宁大连116622 [2]大连大学附属医院,辽宁大连116021

出　　处：《大连大学学报》2002年第6期94-98,共5页Journal of Dalian University

摘　　要：[目的]探讨E-钙粘素(E-Cad)表达与大肠癌发生发展及预后的关系.[方法]采用S.P免疫组织化学染色技术,检测30例大肠腺瘤,60例大肠癌组织E-Cad的表达情况.[结果]E-Cad的表达率在大肠腺瘤中为87.10％,显著高于大肠癌中的55.00％(P<O.05);其表达随着大肠癌分化程度的降低而减少,与淋巴结转移及远隔脏器转移(P<0.05)呈负相关,E-Cad表达率越高患者的预后越好(P<0.05).[结论]E-Cad的表达与分化程度(P<0.05)、生存期(P<0.01)呈正相关,与淋巴结转移(P<0.05)、远隔脏器转移(P<0.05)呈负相关,E-Cad的检测可以成为临床判断大肠癌的恶性程度、转移及预后的重要参考指标.[Objective] To investingate the role of the expression of E-cadherin (E-Cad) in carcinogensis and progression of colorectal cancer(CRC). [Methods] The E-Cad expression was studied immuneohistochemistrically in 30 specimens of colorectal adenoma and 60 specimens of CRC. [Results] The expression rates of E-Cad was 87.10% in colorectal adenoma and 55.00% in CRC, the former was apparently higher than the later (P<0.05); The significant relationship was observed between low E-Cad expression and cellular dedifferentiation and poor prognosis and negative correlation to metastasis of lymph node and distant organs. [Conclusions] The expression rate of E - Cad is positive correlation to differentiative degree and survive time and negative correlation to metastasis of lymph node and distant organs. The detection of expression about E-Cad may be helpful to judge the malignant behavier, metastasis and prognosis with colorectal carcinoma.

关 键 词：E-钙粘素 大肠癌侵润 大肠癌转移 E-CAD 恶性生物学行为 粘附分子 

分 类 号：R735.34[医药卫生—肿瘤]