纳他霉素的分子生物学研究进展  

PROGRESS IN MOLECULAR BIOLOGY OF NATAMYCIN

作　　者：邬建国[1] 王敏[1] 

机构地区：[1]天津科技大学食品科学与生物工程学院,天津300222

出　　处：《微生物学通报》2003年第5期120-123,共4页Microbiology China

基　　金：天津市自然科学基金资助项目 (No 0 136 0 9511)~~

摘　　要：纳他霉素是一种多烯大环内酯类抗真菌抗生素 ,广泛用于食品防腐。通过综述纳他霉素分子生物学的研究进展 ,揭示了纳他霉素的生物合成基因簇 ,包括纳他霉素 2 6元环的形成基因 (pimS0 pimS4)和修饰基因共 1 6个可读框架 ,并对其编码的蛋白质PKS、PimD、PimJ。Natamycin is a polyene macrolide antifungal antibiotic ,which is wide ly used in the food industry in order to prevent mould contamination .Biosynthe s is gene cluster of natamycin is discovered by the overall of progress in molecul ar biology of natamycin, including 16 open reading frames which includes the gen e for 26-member ring formation of natamycin (pimS0-pimS4 ) and the modifying gene s, and the function of the protein including polyketide synthases(PKSs)、PimD、P imJ、PimK were studied

关 键 词：纳他霉素 生物合成 基因簇 聚酮合成酶 

分 类 号：TQ465[化学工程—制药化工]