Study of apolipoprotein E genetic polymorphism in patients with atherosclerotic cerebral infarction  

作　　者：罗本燕 陈智 陈峰 李霞 潘小平 

机构地区：[1]DepartmentofNeurology [2]InstituteofInfectiousDiseases,TheFirstAffliatedHospital,MedicalCollege,ZhejiangUniversity,Hangzhou310003,China

出　　处：《Journal of Zhejiang University Science》2003年第6期749-752,共4页浙江大学学报（自然科学英文版）

摘　　要：Objective: To explore the frequency and significance of ApoE gene polymorphisms in Chinese patients with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P<0.05). The prevalence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group ( P = 0.011) . Conclusions: 465C/G,462C/G and 451delC polymorphisms might be associated with ACI.486GT allele might have protective effect on the pathogenesis of ACI.Objective : To explore the frequency and significance of ApoE gene polymorphisms in Chinese patiems with atherosclerotic cerebral infarction (ACI). Methods: Polymerase chain reaction and gene sequencing, single nucleotide polymorphisms of ApoE gene were used to analyze 33 cases of patients with ACI and 35 controls. Results: The frequencies of ApoE gene single nucleotide polymorphisms 465C/G, 462C/G and 451delC in the ACI group were significantly higher than those in the control group (P <0.05) . The preva-lence of polymorphism 486G/T in the control group was significantly higher than that in the ACI group ( P =0.011 ). Conclusions : 465 C/G, 462C/G and 451 delC polymorphisms might be associated with ACI. 486GT allele might have protective effect on the pathogenesis of ACI.

关 键 词：Cerebral infarction ATHEROSCLEROTIC GENETICS ApoE allele Single nucleotide polymorphism 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R394[医药卫生—临床医学]