氧运输系统对缺氧反应的研究进展  

Advance in Studing on the Mechanism of Reaction to Hypoxia

作　　者：王蕴红[1] 梁蕾[1] 关英华[1] 

机构地区：[1]首都体育学院生理教研室

出　　处：《首都体育学院学报》2001年第3期65-68,共4页Journal of Capital University of Physical Education and Sports

摘　　要：大量研究证实血红素蛋白或NAD(P)H氧化酶是缺氧感受器，并由此引起一系列缺氧的信号传导过程，包括cAMP、Ca2＋、NO、CO、cGMP等信使分子的参与，最终激活缺氧诱导因子-1（HIF-1）使机体产生缺氧反应。还有人认为线粒体参与这一过程，而且可能是缺氧感受器，此外，HIF-1和缺氧反应基因（HRG）的转录调控机制也参与了缺氧过程。：Evidence has accumulated that the O2 sensors have been the identity as flavoheme protein or NAD(P)H oxidase which invokes a series sensory transduction. Among the candidates for O2 sensor are camp, Ca2+, NO, CO, camp mitochondria cytochrome aa3 complex which activited HIF-1 and regulation of HRG gene express by HIF-1 has also been investigated.

关 键 词：缺氧反应 线粒体 NAD(P)H氧化酶 血红素蛋白 HIF—1 

分 类 号：G804.7[文化科学—运动人体科学]