supported by research grants from the National Natural Science Foundation of China(No.81101520);the National Basic Research Program of China(973 program)(No.2013CB910304 and 2012CB967004)
Introduction:Oncogenic aaivation of the K-ras gene occurs in >90%of pancreatic ductal carcinoma and plays a critical role in the pathogenesis of this malignancy.Increase of reactive oxygen species(ROS) has also been o...