EGFR和HER2联合过度表达在食管癌中的意义  

Co-overexpress of EGFR and HER2 in Esophageal Cancer

作　　者：葛棣[1] 曾亮[1] 冯明祥[1] 

机构地区：[1]复旦大学附属中山医院胸外科,上海200032

出　　处：《中国临床医学》2003年第5期699-701,共3页Chinese Journal of Clinical Medicine

摘　　要：目的 :分析EGFR和HER2的联合过度表达在食管癌发生发展过程中的作用及与预后的关系。方法 :采用免疫组化技术 ,检测 4 5例食管癌根治术患者肿瘤组织中EGFR和HER2的表达。结果 :在食管癌中EGFR和HER2的联合过度表达率为2 5 %。EGFR和HER2联合过度表达与食管癌的分化程度和肿瘤的局部浸润程度无关 ,在N1期患者中两者的联合过度表达高于N0 期患者。联合过度表达者的预后较差。结论 :EGFR和HER2联合过度表达在食管癌转移方面可能起着重要的作用 ,属于肿瘤发生发展、演进过程中的后期事件。Objective: To investigate the co-overexpression of EGFR and HER2 in esophageal cancer and its relation with prognosis. Methods: EGFR and HER2 of 45 cases of esophageal cancer were detected using the immunohistochemitry method. Results: Co-overexpression of EGFR and HER2 were present in 25% of the samples. There was no correlation between co-overexpression and tumor differentiation or local invasion. The percentage of co-overexpression was higher in N1 cases than that in N0 cases. The patients with co-overexpression had worse prognosis. Conclusion: Co-overexpression of EGFR and HER2 might have a role in lymph node metastasis in esophageal cancer. It was a late event in the progress of esophageal cancer. Co-overexpression of EGFR and HER2 was a negative marker for the prognosis of esophageal carcinoma.

关 键 词：EGFR HER2 过度表达 食管癌 预后 

分 类 号：R735.1[医药卫生—肿瘤]