ANTITUMOR　ACTIVITY　OF　IMMUNOCONJUGATES　COMPOSED　OF　BOANMYCIN　AND　MONOCLONAL　ANTIBODY  

作　　者：甄永苏 彭泽 邓甬川 许鸿章 陈毓仙 田佩玉 李电东 江敏 

出　　处：《Chinese Medical Sciences Journal》1994年第2期75-80,共6页中国医学科学杂志（英文版）

摘　　要：Boanmycin (bleomycin A6 . BM) . an antitumor antibiotic, was conjugated to monoclonal antibodies including R19, H 111 and CCT2. The immunoconjugates exhibited selective cytotoxicity to related target cells including cecum cancer Hce-8693 cells, liver cancer BEL-7402 cells and leukemia CEM cells. They were highly effective against related human tumor xenografts in nude mice, and the inhibition rates by the conjugates were much higher than those by free BM. The inhibition rate by R19-BM conjugate against human cecum cancer xenografts reached 90%. BY immunoelectron microscopy, CCT2-BM conjugate showed specific binding and internalization in leukemia CEM cells. The results indicate that boanmycin-monoclonal antibody immunoconjugates are highly active both in vitro and in vivo.

关 键 词：IMMUNOCONJUGATE bleomycin A6 tumor xenografts 

分 类 号：R73-3[医药卫生—肿瘤]