IMMUNOCONJUGATE

作品数：7被引量：11H指数：2
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Preparation of Anti-HER2 Monoclonal Antibody-paclitaxel Immunoconjugate and Its Biological Evaluation被引量：1
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第6期735-740,共6页刘东 徐艳娇 饶子超 陈兆聪 
supported by a grant from the National Natural Science Foundation of China(No.30300429)
Anti-HER2 monoclonal antibody （Sc7301）-paclitaxel （TAX） immunoconjugate was pre- pared and its specific binding to tumor cells was investigated in this study. Sc7301 was conjugated to TAX by the active ester metho...
关键词：PACLITAXEL anti-HER2 monoclonal antibody IMMUNOCONJUGATE specific binding 
Antitumor effects of the molecule-downsized immunocon-jugate composed of lidamycin and Fab' fragment of monoclonal antibody directed against type IV collagenase被引量：7
《Science China(Life Sciences)》2004年第1期66-73,共8页WANG Fengqiang SHANG Boyang ZHEN Yongsu 
Type IV collagenase plays an important role in tumor invasion and metastasis through cleaving type IV collagen in the basement membrane and extracellular matrix. In this study a molecule-downsized immunoconjugate (Fab...
关键词：anti-type IV COLLAGENASE MONOCLONAL antibody  immunoconjugate  lidamycin  antibody-based drug. 
Chemical conjugation of a novel antibody interleukin 2 immunoconjugate against c erbB 2 product被引量：3
《Chinese Medical Journal》2000年第2期55-57,共3页李君 Sharon E Lee Marie Belciug David B Ring Cheuk S Kwok 
Objective To develop a new chemical method to produce a monoclonal antibody (MoAb) 520C9/recombinant human interleukin 2 (rhIL 2) conjugate Methods MoAb 520C9 reactive with the protooncogene c erbB 2 product P...
关键词：interleukin 2 monoclonal antibody CONJUGATION 
Localization　and　Biodistribution　of　Conjugate　ATG－Dex－DNR　in　Nude　Mice　as　Models　for　Human　Leukemia
《Journal of Huazhong University of Science and Technology(Medical Sciences)》1995年第2期82-86,共5页张东华 唐锦治 李志雄 崔武任 吴华 朱慧芬 沈关心 
I-labelled anti-thymoglobuline (ATG), 131 I-labelled immunoconjugate ATG-Dex-DNR and 131 I-labelled Ts-MoAb as control antibody, respectively.were injected by intraperitoneal (i. p.) administration into nude mice used...
关键词：ATG IMMUNOCONJUGATE RADIOIMMUNOIMAGING human leukemia modelbearing nude mice 
EXPERIMENTAL　STUDY　ON　ANTITUMOR　EFFECT　OF　MONOCLONAL　ANTI－IDIOTYPIC　ANTIBODY－DNR　CONJUGATE　TO　LEUKEMIA
《Chinese Journal of Cancer Research》1995年第1期20-23,共4页王晓林 曹熙芳 朱慧芬 苏娜 张悦 沈关心 
In this experiment,the Dcxtran-T40(Dex-T40) served as intermidiate carrier,conjugated SM6 monoclonal antiidiotypic antibody(anti-Id-McAb) against B lymphocytic leukemia cells and chemotherapeutical drug daunorubicin(D...
关键词：IMMUNOCONJUGATE Anti-Id-McAb Cytotoxic assay. 
ANTITUMOR　ACTIVITY　OF　IMMUNOCONJUGATES　COMPOSED　OF　BOANMYCIN　AND　MONOCLONAL　ANTIBODY
《Chinese Medical Sciences Journal》1994年第2期75-80,共6页甄永苏 彭泽 邓甬川 许鸿章 陈毓仙 田佩玉 李电东 江敏 
Boanmycin (bleomycin A6 . BM) . an antitumor antibiotic, was conjugated to monoclonal antibodies including R19, H 111 and CCT2. The immunoconjugates exhibited selective cytotoxicity to related target cells including c...
关键词：IMMUNOCONJUGATE bleomycin A6 tumor xenografts 
POTENTIAL FOR TARGETING HEPATOMA WITH ANTI-FERRITIN IgG-DAUNOMYCIN IMMUNOCONJUGATE
《Chinese Journal of Cancer Research》1991年第3期37-41,共5页陈东泉 陈莉 仲伟强 王仁之 李希强 
Sheep anti-human ferritin IgG (AHFI) and nonspecific normal sheep IgG (NSIgG) were conjugated with Daunomycin (Dau) separately via a mediator Dextran T40. The conjugates (AHFI-Dex-Dau and NSIgG-Dex-Dau) were labelled ...
关键词：tumour targeting HEPATOMA chemo-immunocon jugate. 
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