Background Monoclonal antibodies (mAbs) such as DD3,raised against progastrin-releasing peptide(31-98) (ProGRP(31-98)) antigen,have been used to target small cell lung cancer (SCLC).However,as an intact mAb,...
Background During the process of bone cement joint replacement, some patients show a series of complications, such as a sudden drop in blood pressure or dyspnea. The cause of the complication is considered to be due t...
the grants as fol-lows:The Problems-Tackling Program in Sci-ence and Technology of Guangzhou City,Chi-na(No.2003 Z 3-E0381);National Foundationof Natural Science,China(No.30670951);Guangdong Foundation of Natural Science,Guangdong,China(No.06021322);TheProblems-Tackling Program in Science andTechnology of Guangdong Province,China(No.2005 B31211002).
OBJECTIVE To explore the method of preparation of 99m↑Tc labeled AntiVEGF McAb 5-FU loaded polylactic acid nanoparticles (99m↑TC-5-FU-Ab-NPs), and investigate the biological distribution of the nanoparticles in hu...
This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30200295).
In order to construct a single chain fragment variable (ScFv) phage display library against ovarian tumor, by using RT-PCR, the human heavy chain variable region genes (VH) and light chain variable region genes ...
AIM: To evaluate the multi-step pretargeting radioimmunoimaging (RII) and radioimmunotherapy (RTT) in nude mice bearing human colon carcinoma with avidin-biotin system labeled with 153^Sm. METHODS: Two- and thre...
To evaluate the clinical application of radioimmunoimaging (Rll ) with 99m Tc-BDI-1 in thediagnosis of bladder cancer. Methods 32 pstients with bladder cancer and 5 with normal bladder were studied. Rll was...
National Natural Science Foundation of China,No.39700175
AIM To directly radiolabel an anti-hepatomamAb fragment HAb18 F(ab’)2 with 99mTc bystannous-reduced method,and assess thestability,biodistribution and radioimmun-oimaging(RⅡ).METHODS Immuno...
IM To study the radioimmunoimaging (RAII) using the human/mouse chimeric Ab to evaluate its targeting activity in animal models.METHODS To chimeric Ab was labeled with 131I. RAII was performed at different intervals...
AIM To determine whether Hb3 and its fragment F(ab')2 have practical value in radioimmunoimaging of colorectal cancer.METHODS Intact Hb3 was purified by hydroxylapatite chromatography. The fragment F(ab')2 was prepare...
In this study, the human breast cancer-bearing nude mice model has been established and the radioim-munoimaging was carried out by using human anti-human monoclonal antibodies. The results showed that the breast tumor...