FRAGMENTS

作品数：304被引量：505H指数：10
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ADAM8 inactivation modulates cellular component assembly gene expression in the mouse intervertebral disc
《Genes & Diseases》2025年第3期54-56,共3页Ken Chen Zuozhen Tian Motomi EnomotoIwamoto Yejia Zhang 
Dear Editor ADAM8(ADAM metallopeptidase domain 8,aka MS2/CD156/CD156a)is a membrane-anchored proteinase.ADAM8 and its proteolytic product,fibronectin fragments,are elevated in degenerative human intervertebral discs(I...
关键词：degenerative human intervertebral discs ivds degenerative disc diseasea Intervertebral Disc fibronectin fragments DEGENERATION Adam Fibronectin Fragments Gene Expression 
Exploring Protein Bioconjugation:A Redox-Based Strategy for Tryptophan Targeting
《Research》2025年第1期578-580,共3页Qian-Qian Yang Shuai-Jiang Liu Wei Huang Cheng Peng Bo Han 
financial support from the National Natural Science Foundation of China(82374020 and 82374155);Science and Technology Department of Sichuan Province(2023ZYD0054 and 2024NSFTD0023);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202209).
Amino acid bioconjugation technology has emerged as a pivotal tool for linking small-molecule fragments with proteins,antibodies,and even cells.The study in Nature by Chang and Toste introduces a redox-based strategy ...
关键词：click reactionsmeanwhilethis small molecule fragments protein bioconjugation redox based strategy tryptophan targeting amino acid bioconjugation oxidative cyclization reagentsdemonstrating 
Modular Access to Chiral 1,3-Substituted Fragments via Nickel-Catalyzed Arylboration Reaction
《Chinese Journal of Chemistry》2025年第3期261-267,共7页Yang Bao Tong Yao Weiyu Kong Yangyang Li Ying Fu Dong Wu Guoyin Yin 
supported by Guangdong Basic and Applied Basic Research Foundation(2024A1515011689).
Chiral 1,3-substituted fragments are ubiquitous in pharmaceutical molecules and natural products,prompting the development of numerous methods to access these structures.Nonetheless,devising synthetic routes for compl...
关键词：ALKENES Nickel Chiral 1 3-bis(boronates) Chain-walking Carboboration ENANTIOSELECTIVITY 
Self-assembly of tau fragments as a key pathologic event in tauopathies
《Neural Regeneration Research》2024年第12期2565-2566,共2页Ly Thi Huong Luu Le Jung Hoon Lee Min Jae Lee 
supported by grants from the National Research Foundation of Korea (2021 R1A2C2008023,2020R1A5A 1019023;RS-2023-00261784 to MJL;2021R1/1A1A 01051245to JHL)。
Tau protein is encoded by the microtubuleassociated protein tau(MAPT)gene and stabilizes microtubules in the neurons.Tau has unique biophysical properties that make it both highly water-soluble and positively charged....
关键词：TAU PATHOLOGIC assembly 
Analgesic Effect of 35 kDa Hyaluronan Fragment on Vaginal Oocyte Retrieval Operation-Associated Pain: A Case Report
《Case Reports in Clinical Medicine》2024年第12期503-511,共9页Hua Zhang Dylan Treger Xiaoxiao Jia Zhaohui Ma Mizhou Hui 
Transvaginal oocyte retrieval (TVOR) is a common yet painful procedure in assisted reproductive technologies (ART) like in vitro fertilization (IVF). Effective pain management during and after TVOR is essential, parti...
关键词：Transvaginal Oocyte Retrieval 35 kDa Hyaluronan Fragments HA35 ANALGESIA Pain Relief Wound Healing 
Evaluation of albumin and lactate dehydrogenase in comparison with cytokeratin 19 fragments and neuronspecific enolase as diagnostic biomarkers for non-small cell lung cancer
《iLABMED》2024年第4期227-237,共11页Xiaodong Feng Ning Yuan Wei Xu Yingying Ji Xiaoyan Yu Zhijun Zhang 
Natural Science Foundation of Shandong Province,Grant/Award Number:ZR2020QH283;National Natural Science Foundation of China,Grant/Award Number:82002226;Tai'an City Science and Technology Development Plan Project,Grant/Award Numbers:2022NS332,2022NS212;Nursery Project of the Affiliated Tai'an City Central Hospital of Qingdao University,Grant/Award Number:2022MPM01。
Background:The diagnosis of non-small cell lung cancer(NSCLC)is a clinical issue that requires attention,and more practical and effective biomarkers need to be selected to assist in diagnosis.This study aimed to exami...
关键词：ALBUMIN biomarkers lactate dehydrogenase non-small cell lung cancer receiver operating characteristic 
Regeneration and colonization abilities of invasive and native Myriophyllum species under different fragment types and lengths
《Journal of Plant Ecology》2024年第6期279-290,共12页Min Zou Xiao-Wen Lin Xiao-Dong Wu Yuan Qin Xu-Guang Ge Jian-Jun Hou Xiao-Xia Li Shuang Peng 
supported by the Open Foundation of Hubei Key Laboratory of Pollutant Analysis&Reuse Technology(Hubei Normal University)(PA220103);the Open Foundation of Resource-exhausted City Transformation and Development Research Center(Hubei Normal University)(KF2024Y07);the Open Project Funding of Key Laboratory of Intelligent Health Perception and Ecological Restoration of Rivers and Lakes,Ministry of Education,Hubei University of Technology(HGKFYBP03);the College Students’Innovative Entrepreneurial Training Plan Program(202310513013,S202310513064).
Alien invasive species usually have strong regeneration and colonization abilities.However,whether invasive species have advantages in terms of regeneration and colonization abilities over native species requires furt...
关键词：Myriophyllum aquaticum M.spicatum REGENERATION COLONIZATION FRAGMENTS biological invasion 
An equivalent target plate damage probability calculation mathematics model and damage evaluation method
《Defence Technology（防务技术）》2024年第11期82-103,共22页Hanshan Li Xiaoqian Zhang 
supported by National Natural Science Foundation of China (Grant No. 62073256);the Shaanxi Provincial Science and Technology Department (Grant No. 2023-YBGY-342)。
Aiming at the requirement of damage testing and evaluation of equivalent target plate based on the explosion of intelligent ammunition, this paper proposes a novel method for damage testing and evaluation method of ci...
关键词：Target damage evaluation Damage probability FRAGMENTS Equivalent target plate Image processing 
A cloud model target damage effectiveness assessment algorithm based on spatio-temporal sequence finite multilayer fragments dispersion
《Defence Technology（防务技术）》2024年第10期48-64,共17页Hanshan Li Xiaoqian Zhang Junchai Gao 
supported by National Natural Science Foundation of China(Grant No.62073256);the Shaanxi Provincial Science and Technology Department(Grant No.2023-YBGY-342).
To solve the problem of target damage assessment when fragments attack target under uncertain projectile and target intersection in an air defense intercept,this paper proposes a method for calculating target damage p...
关键词：Target damage Cloud model Fragments dispersion Effectiveness assessment Spatio-temporal sequence 
Remnants and fragments of the subducted paleo-Pacific plate:Constraints from geochemistry and geophysics
《Science China Earth Sciences》2024年第10期3041-3061,共21页Xisheng XU Zhouchuan HUANG Dingsheng JIANG Gang ZENG Li-Qun DAI 
supported by the National Key R&D Program of China (Grant Nos.2022YFF0800404,2022YFF0800402)。
The subduction and rollback of the paleo-Pacific plate during Mesozoic time was the key engine for the evolution of the continental margin in eastern China. It led to lateral accretion of continental crust in Northeas...
关键词：Paleo-Pacific plate Big mantle wedge Late Mesozoic Remnants and fragments GEOCHEMISTRY GEOPHYSICS 
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