神经精神病学临床评定表(SCAN)在精神分裂症临床表型界定中的应用  

The Role of SCAN in Clinical Classification of Patients with Schizophrenia

作　　者：原岩波[1] 舒良[1] 

机构地区：[1]北京大学精神卫生研究所,100083

出　　处：《中国心理卫生杂志》2003年第11期774-777,共4页Chinese Mental Health Journal

摘　　要：目的 :使用半定式诊断工具神经精神病学临床评定表 (SCAN)进行有关精神分裂症临床表型界定方面的探索。方法 :对初步诊断为精神分裂症的住院患者使用SCAN核实ICD -10诊断 ,共收集 80例 ,采用SCAN诊断软件辅助诊断并得出症状组和症状群资料 ,用主成分分析等方法进行处理。结果 :根据对SCAN症状群的主成分分析 ,精神分裂症的临床相可以划分为以精神病性症状、阴性症状和抑郁症状为主的三个维度 ;而精神病性症状内部可以区分出特征性幻听、思维障碍和被动体验、怪异妄想以及非特异性病理症状四个维度的划分。结论 :根据精神分裂症临床相的维度划分 ,提出按照操作性标准 (如一级症状 )、阴性症状和情感症状三级标准划分临床表型的假说。Objective: To explore the classification of clinical phenotype of schizophrenia using Schedules for Clinical Assessment in Neuropsychiatry (SCAN). Methods: For inpatients preliminarily diagnosed as schizophrenia, SCAN was used to check the diagnosis (ICD-10 criteria). A total of 80 patients were collected. SCAN diagnostic software was used to help make diagnosis and to output the data of symptom groups and syndromes. Data were analyzed by principal component analysis. Results: Based on the principal component analysis, The clinical symptoms of schizophrenia were divided into three dimensions mainly characteristic of psychotic, negative and depressive symptoms; the psychotic dimension were further divided into four factors: characteristic audible hallucination, thought formal disorder, bizarre delusions and non-specified psychotic symptoms. Conclusion: Clinical subgroups with three steps are established and preliminarily validated.

关 键 词：神经精神病学临床评定表 SCAN 精神分裂症 临床表型 界定 应用 

分 类 号：R749.3[医药卫生—神经病学与精神病学]