危重患者抗氧化维生素血浆水平观察  

Antioxidant Vitamin Concentrations in Plasma of Critically Ill Patients

作　　者：于黎华[1] 蔡威[1] 汤庆娅[1] 陶晔璇[1] 王莹[1] 冯一[1] 费延文[1] 

机构地区：[1]上海第二医科大学附属新华医院临床营养中心,上海200092

出　　处：《中国临床营养杂志》2003年第4期305-308,共4页Chinese Journal of Clinical Nutrition

摘　　要：目的了解危重患者体内抗氧化维生素水平。方法2002年5月～2003年2月间新华医院外科ICU收治的112例危重患者,采用高效液相法测定体内抗氧化维生素水平。结果112例危重患者抗氧化维生素水平明显低于正常对照组眼维生素A:(33.8±25.1)μg/dLvs(78.2±31.2)μg/dL,P=0.000;维生素E:穴6.5±4.4雪mg/Lvs(10.1±6.2)mg/L,P=0.000;β-胡萝卜素:(184±185)μg/Lvs(756±794)μg/L,P=0.000;维生素C:(5.0±4.2)mg/Lvs(6.7±3.9)mg/L,P=0.000演。危重患者中各维生素缺乏症发生率高于正常人,分别为维生素A:25.9%vs0%(P=0.000);维生素E:44.6%vs17.0%(P=0.000);β-胡萝卜素:46.4%vs12.8%(P=0.000);维生素C:62.5%vs31.2%(P=0.000)。危重患者中男性维生素A水平明显高于女性眼分别为(38.8±26.2)μg/dLvs(26.2±21.5)μg/dL,P=0.012演,且随年龄增长,维生素A水平显著降低(r=-0.234,P=0.015)。抽血日前禁食天数>7d组患者与≤7d组患者相比,各抗氧化维生素呈下降趋势,但无统计学差异。结论危重患者血浆维生素A、E和β-胡萝卜素水平明显低于正常人,且该人群中抗氧化维生素缺乏非常普遍。Objective To know the plasma concentration of antioxidant vitamins in critically ill p atients. Methods 112surgical patients(68male and44female)with APACHE Ⅱ score equal or more than5were in need of intensive care.Vitamin A,E,C an d a-carotene concentrations were determined by high-performance liquid chromatography. Results Antioxidant vitamin concentrations were significantly lower in critically il l patients than those in normal volunteersAntioxidant Vitamin Concentrations in Plasma of Critically Ill Patients $$$$ Yu Li-hua Cai Wei # Tang Qing-ya Tao Ye-xuan Wang Ying Feng Yi Fei Yan-wen (Clinical Nutrition Center,Xin Hua Hospital,Shanghai Second Medical Unive rsity,Shanghai200092,China) abstract Objective To know the plasma concentration of antioxidant vitamins in critically ill p atients. Methods 112surgical patients(68male and44female)with APACHE Ⅱ score equal or more than5were in need of intensive care.Vitamin A,E,C an d a-carotene concentrations were determined by high-performance liquid chromatography. Results Antioxidant vitamin concentrations were significantly lower in critically il l patients than those in normal volunteers[vitamin A:(33.8ì g/ dL vs (78.2ì g/ dL, P< 0.001;vitamin E:(6.5/ L vs (10.1/ L, P< 0.001; a-carotene:(184ì g/ L vs (756ì g/ L, P< 0.001;vitamin C:(5.0/ L vs (6.7/ L, P <0.001).Additionally,vitamin deficiency in critically ill patients was higher than that in control group(vitamin A:25.9% vs 0%, P= 0.000;vitamin E:44.6% vs 17.0%, P= 0.000; a-carotene :46.4% vs 12.8%, P= 0.000;vitamin C :62.5% vs 31.2%, P= 0.000).The mean plasma level of vitamin A in male patients was higher than that in female patients( P< 0.05).The relationship between age and vitamin A was significantly neg ative correlation( r=-0.234 ,P= 0.015).The other three vitamins were not associated with age.The mor e the length of fasting before blood taken,the lower mean concentrations of fou r antioxidant vitamins,but there was no significance. Conclusions Plasma antioxidant vitamin concentrations in critically i

关 键 词：危重患者 抗氧化维生素 高效液相法 维生素A 维生素E2 Β-胡萝卜素 维生素C 

分 类 号：R459.3[医药卫生—治疗学]