脑胶质瘤组织中cyclin D1的表达及其意义  

Expression of Cyclin D1 in Brain Gliomas and Its Significance

作　　者：谭平国[1] 邢洲[2] 李则群[1] 

机构地区：[1]中山大学第二附属医院神经外科,广东广州5101202 [2]广州医学院第二附属医院神经外科,广东广州510008

出　　处：《癌症》2004年第1期63-65,共3页Chinese Journal of Cancer

摘　　要：背景与目的:细胞周期素D1(cyclinD1)在许多肿瘤中有过度表达,过量的cyclinD1是许多肿瘤发生的重要原因。但在脑胶质瘤中是否存在cyclinD1的过度表达尚有争论,本研究旨在检测人脑胶质瘤组织中cyclinD1的表达水平,探讨cyclinD1与脑胶质瘤恶性程度及预后的关系。方法:采用免疫组化SP法检测84例脑胶质瘤组织中cyclinD1的表达水平;分析脑胶质瘤组织中的cyclinD1表达强度、阳性细胞率与肿瘤恶性程度、预后之间的关系。结果:(1)32例低级别胶质瘤中cyclinD1平均阳性细胞率为(9.82±9.75)%,52例高级别胶质瘤中平均阳性细胞率为(27.45±21.03)%,两组均数比较差异有显著性(P<0.01);(2)低级别胶质瘤cyclinD1阳性率为31.25%(10/32),高级别胶质瘤阳性率为61.53%(32/52),差异有显著性(P<0.01);(3)复发组cyclinD1阳性率为76.19%(16/21),未复发组的cyclinD1阳性率为24.00%(6/25),差异有显著性(P<0.01);(4)死亡组cyclinD1阳性率为66.67%(14/21),未死亡组的cyclinD1阳性率为32.00%(8/25),差异有显著性(P<0.05)。死亡组21例中,高级别胶质瘤cyclinD1阳性率为86.66%(13/15),低级别胶质瘤阳性率为16.66%(1/6),差异有显著性(P<0.01)。结论:CyclinD1表达水平随胶质瘤病理分级的增高而增高;cyclinD1表达水平越高,患者预后越差。BACKGROUND &OBJECTIVE: Overexpression of cyclin D1 was shown in ma ny tumors. The excessive expression of cyclin D1 is an important cause of many t umors. But there are still some controversies of whether the overexpression of c yclin D1 exists in brain gliomas. This study was to determine the expression lev el of cyclin D1 in glioma tissues of human brain, and to analyze the relationshi p of cyclin D1 with the malignancy and prognosis of gliomas. METHODS: The expres sion levels of cyclin D1 in 84 specimens were determined by SP immunohistochemic al assay. The correlation of expression intensity of cyclin D1, positive cell ra tio of glioma tissues with the tumors malignancy, and the prognosis of the patie nts was analyzed. RESULTS:(1) The average percentages of cyclin D1 positive cell s were (9.82±9.75)%and (27.45±21.03)%in the low grade gliomas and the high g rade gliomas, respectively. There was significant difference between two groups (P< 0.01). (2) The cyclin D1 positive ratios were 31.25%(10/32) and 61.53%(32/ 52) in the low grade gliomas and the high grade gliomas, respectively. There was significant difference between two groups (P< 0.01). (3) The cyclin D1 positive ratios were 76.19%(16/21) and 24.00%(6/25) in recurrence group and non-recur rence group,respectively. There was significant difference between two groups (P < 0.01). (4) The cyclin D1 positive ratios were 66.67%(14/21) and 32.00%(8/25) in dead group and survival group, respectively. There was significant differenc e between two groups (P< 0.05). In dead group, the cyclin D1 positive ratios wer e 86.66%(13/15) and 16.66%(1/6) in the high grade gliomas and the low grade gl iomas, respectively. There was significant difference between two groups (P< 0.0 5).CONCLUSIONS:(1) The expression of cyclin D1 increased with the increased grad e of glioma. (2) The higher cyclin D1 expressed, the worse prognosis the patient s had. (3) The expression of cyclin D1 can act as a biological marker in evaluat ing malignancy of gliomas and prognosis of patie

关 键 词：脑胶质瘤 CYCLIN D1 表达 瘤组织 细胞周期素D1 肿瘤发生 

分 类 号：R739.4[医药卫生—肿瘤]