Synthetic studies toward resveratrol-based natural products polynapstilbenes A and B  

白藜芦醇衍生天然产物Polynapstilbenes A和B的合成研究（英文）

作　　者：Baiyang Jiang Lingqi Qiu Jinrong liu Hanxuan Wang Suwei Dong 蒋柏阳;邱凌琪;刘锦荣;王翰轩;董甦伟(北京大学药学院天然药物及仿生药物国家重点实验室化学生物学系)

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs,Department of Chemical Biology,School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing 100191,China

出　　处：《Journal of Chinese Pharmaceutical Sciences》2019年第9期595-604,共10页中国药学（英文版）

基　　金：Peking University Health Science Center(Grant No.BMU20130354);State Key Laboratory of Natural and Biomimetic Drugs,and the National Recruitment Program of Global Youth Experts(1000 Plan)

摘　　要：Resveratrol-based natural products have received considerable attention as synthetic targets due to their versatile bioactivities and unique structures.Herein,we disclose our efforts toward the syntheses of polynapstilbenes A and B,which possess[C8-O-C-C-C7]-type dihydrobenzofuran skeleton that is distinctive compared with the other reported resveratrol-derived natural products.Our approach,featuring an acid-catalyzed conjugate addition followed by cyclization of para-quinone methides and phenols,affords two advanced intermediates that represents the dimethyl-protected aglycon of polynapstilbenes A and B.本文报导了一种区域选择性合成基于白藜芦醇的[C8-O-C-C-C7]二氢苯并呋喃天然产物骨架的方法,并据此合成了天然产物Polynapstilbenes A和B的合成中间体。

关 键 词：RESVERATROL Polynapstilbenes A and B DIHYDROBENZOFURAN 

分 类 号：R914[医药卫生—药物化学]