慢性肝病患者血清透明质酸测定及其临床意义  

Clinical Significance of Serum Hyaluronic Acid Determination in Chronic liver Diseases

作　　者：田维铨[1] 余裕民[2] 李向荣[3] 赵久法[1] 李志军[1] 吴炎[4] 程光亮[2] 邬亦贤[1] 

机构地区：[1]蚌埠医学院附院传染病科,233004 [2]蚌埠医学院核医学教研室 [3]蚌埠市传染病医院肝炎科 [4]蚌埠医学院附院消化科

出　　处：《天津医药》1992年第6期333-335,共3页Tianjin Medical Journal

摘　　要：本文报告用RIA测定88例慢性肝病患者血清透明质酸(HA)的水平。结果如下:1.随着肝病病程的进展,患者血清HA水平逐渐增高,即肝硬化(445.95±123.68μg/L)>慢活肝(224.71±54.95μg/L)>慢迁肝(82.13±33.81μg/L)>正常对照组(47.57±17.54μg/L)(均P<0.01)。2.肝硬化患者按Child分级,A级(321.14±37.17μg/L)<B级(429.00±31.90μg/L)<C级(573.07±66.72μg/L)(均P<0.01)。大多数肝硬化患者(34/37.92％),血清HA大于300μg/L。肝硬化患者的血清HA水平与血清白蛋白、γ-球蛋白、凝血酶原时间密切相关,而与血清胆红素、ALT无相关。Serum hyaluronic acid (HA) was measured by radioimmunoassay (RIA) in 88patients with chronic liver diseases. The principal findings were the following, 1. Asthe liver disease progressed serum HA levels increased in the following decreasingorder, in liver cirrhosis (LC) (445.57±123.68μg/L), chronic active hepatitis (CAH)(224.71±54.95μg/L), chronic persistent hepatitis (CPH) (82.13±33.81μg/L) and thecontrols (47.57±17.54μg/L) (P<0.01). 2. Serum HA concentrations in LC patientswith Child A, B and C were 321.14±37.17μg/L, 429.00±31.90μg/L and 573.07±66.72μg/L, respectively. Serum HA level was the highest in Child C and the lowestin Child A. Most of the LC cases had serum HA values over 300μg/L. Serum HAwas significantly correlated with serum albumin, γ-globulin and prothrombin timebut not with total serum bilirubin and ALT.

关 键 词：慢性 迁延型 肝炎 活动型 透明质酸 

分 类 号：R575.1[医药卫生—消化系统]