Anti-aging effect of astragalosides and its mechanism of action  

黄芪总甙延缓衰老的作用及其机制(英文)

作　　者：雷红[1] 王斌[1] 李卫平[1] 杨雁[1] 周爱武[1] 陈敏珠[1] 

机构地区：[1]安徽医科大学临床药理研究所

出　　处：《Acta Pharmacologica Sinica》2003年第3期230-240,共11页中国药理学报（英文版）

摘　　要：AIM: To study the anti-aging effect of astragalosides (AST) and its mechanism of action. METHODS: Rotating rod test and step-down type passive avoidance test were performed to determine the effects of AST on motor and memory of D-galactose (D-gal)-induced senescent mice and the middle-aged mice. The proliferative response of splenocytes induced by Con A or LPS, IL-2 production of splenocytes induced by ConA of D-gal-treated mice and the middle-aged mice were also measured. RESULTS: AST (40 mg-kg^(-1).d^(-1), ig, for 10 weeks) was found to ameliorate age-related alternations in both motor response and memory, enhance the deteriorated cellular immunity in D-gal-treated mice and the pre-aged (17-month-old) mice. CONCLUSION: AST has an anti-aging effect on D-gal-induced senescent mice and has the effect of delaying senility of the middle-aged mice, which was related to its improvement of brain function and immunomodulatory effects.目的:研究黄芪总甙(astragalosides,AST)延缓衰老的作用及其机制。方法:采用小鼠D-半乳糖(D-galactose,D-gal)人工衰老模型和自然衰老模型(17月龄),以小鼠协调运动、学习记忆、以及免疫功能作为指标,同步观察药物的作用。结果:AST(40mg·kg^(-1)·d^(-1),ig,10周)可明显恢复D-gal衰老小鼠的协调运动和学习记忆功能,使其过低的ConA诱导脾淋巴细胞增殖反应及IL-2产生明显升高,但对LPS诱导B淋巴细胞增殖反应无明显影响。AST(40mg·kg^(-1)·d^(-1),ig,3个月)对17月龄小鼠亦有类似作用。结论:AST对D-gal衰老小鼠和由中年期(14月龄)进入老前期(17月龄)小鼠的自然衰老进程均有明显的延缓作用,可能与其免疫调节作用有关。

关 键 词：ASTRAGALOSIDES AGING GALACTOSE motor activity MEMORY 

分 类 号：R285[医药卫生—中药学] R282.71[医药卫生—中医学]