深圳地区1657例不良生育史的染色体分析  

Chromosome Analysis for 1657 cases with abnormal reproduction history from ShenZhen area

作　　者：宋丹[1] 钱卫平[1] 许晓清[1] 田菁燕[1] 谭玉梅[1] 吴有利[1] 

机构地区：[1]广东省深圳市罗湖医院生殖中心,广东深圳518001

出　　处：《河北医学》2003年第11期986-988,共3页Hebei Medicine

摘　　要：目的 :探讨染色体异常及变异与不良生育史的关系。方法 :对深圳地区 16 5 7例因不良生育史就诊者取外周血 ,常规培养 ,制片后G显带行染色体核型分析。结果 :发现染色体异常核型 5 4例 ,异常发生率为 3.2 6 % ,染色体多态变异核型 6 3例 ,变异发生率为 3.80 %。染色体异常率在不良生育史群体中高于一般群体 (0 .5 %～ 1% )。结论 :染色体异常是导致不良生育史的重要原因之一。Objective: To research for the relation between an abnormal history of reproduction and chromosal abnormality or cromosome polymorphisms. Method: Chromosome G-banding was performed to determine the karyotype of 1657 patients with an abnormal reproductive history from ShenZhen area. Results: Among them, 54 cases (3.26%) showed chromosomal abnormalities, and 63 cases (3.80%) had cromosome polymorphisms. Their chromosome abnormality frequency is higher than normal population(0.5%~1%). Conclusion: Chromosome abnormality is one of important causes for abnormal reproduction. Chromosome polymorphism also involve in abnormal reproduction.

关 键 词：不良生育史 染色体异常 核型分析 染色体多态性 深圳地区 

分 类 号：R394[医药卫生—医学遗传学]