表皮生长因子受体介导的PLC-g1水解PIP_2的数学建模  

Mathematical model of epidermal growth factor receptor-mediated lipid phosph atidylinositol(4,5)-bisphosphate hydrolyzation by phospholipase C-gamma1activity

作　　者：苏永春[1] 邓凡[2] 陆地[2] 白晓春[2] 谭小丹[1] 董爱荣[1] 罗深秋[1] 邓亲恺[2] 

机构地区：[1]第一军医大学医学物理学教研室,广东广州510515 [2]第一军医大学细胞生物学教研室,广东广州510515

出　　处：《第一军医大学学报》2004年第1期18-20,23,共4页Journal of First Military Medical University

基　　金：国家自然科学基金(39870381);广东省自然科学基金(020015);军队医学卫生科研基金(01MB098)~~

摘　　要：目的探讨表皮生长因子刺激下磷脂酶C-g1(PLC-g1)水解细胞膜上PIP2(PIP2)的动力学特性。方法根据质量作用定律,利用微分方程对PIP2的代谢途径进行数学建模。结果建立了PIP2水解过程中关键产物浓度的微分方程,分析了各个参数对这些水解产物的影响。结论这个数学模型为进一步描述PIP2代谢循环的生物学特征和主要产物间浓度依赖关系的动态变化奠定了基础。Obje ct ive To investigate the dynamic characteristics of lipid phosphatidylinositol (4, 5)-bisphosphate (PIP 2 ) in plasma membrane hydrolyzed by phospholipase C-gamma1 in epidermal grow th factor receptor(EGFR)-mediated signal path-way. Methods A mathematical model based on the law of mass action was established with differential equations to s imulate metabolizable pathway of PIP 2 . Results Differential equations of the key product concentration during hyd rolysis of PIP 2 were formulated, and the effects of the parameters on these hydrolyzed pro ducts analyzed. Conclusion This mathematical model provides foundation for furt her investigation of the dynamic changes of biological characteristics and the r elations between the key product concentrations in PIP 2 hydrolysis.

关 键 词：表皮生长因子受体 PLC-g1 水解 PIP2 数学建模 磷脂酶C-g1 动力学特性 

分 类 号：R341[医药卫生—基础医学] O29[理学—应用数学]