Effect of Platelet Activation and Endothelial Cell Injury on Malignant Cancer  

血小板活化和内皮细胞损害对恶性肿瘤影响的临床研究(英文)

作　　者：孙达春[1] 张爱华[1] 李小亮[1] 吴红[1] 何志国[1] 

机构地区：[1]珠海市人民医院血液肿瘤科,519000

出　　处：《The Chinese-German Journal of Clinical Oncology》2003年第4期243-245,254,共4页中德临床肿瘤学杂志（英文版）

基　　金：This work was supported by grants from Guangdong Medical Science foundation(A2000633).

摘　　要：Objective: To study the effects of platelet activation and endothelial cell injury on the patients with malignant tumor and their prognoses.Methods: Radioimmunity and ELISA methods were employed to detect the TXB2, GMP-140, vWF, cGMP and FN in 78 cases of malignant tumor and 40 healthy control persons.Results: The levels of TXB2, MP-140 and cGMP were increased in intestinal cancer group, lung cancer group and hepatic cancer group, while FN decreased in intestinal cancer and lung cancer group. cGMP was positively related to TXB2, GMP-140, vWF in malignant tumor group. FN was decreased in the group complicated with infection and the group with metastasis, while the other indexes increased. GMP-140, vWF and cGMP was decreased after operation except for the increasing of FN.Conclusion: Activations of platelet and injury of endothelial cells developed in patients with malignant tumor, and both of them affected the metastasis and prognosis of malignant tumor. Key words platelet activation - epithelium injury - malignant tumor - metastasis This work was supported by grants from Guangdong Medical Science foundation (A2000633).

关 键 词：platelet activation epithelium injury malignant tumor METASTASIS 

分 类 号：R73-3[医药卫生—肿瘤]