原发性肺癌患者外周血内皮抑素检测意义  

Serum Endostatin Levels in Patients with Primary Lung Cancer

作　　者：王颖[1] 石殿鹏[2] 于金明[2] 李道堂[2] 郭其森[2] 

机构地区：[1]山东省医学科学院附属医院检验科,山东济南250062 [2]山东省肿瘤医院,山东济南250117

出　　处：《肿瘤防治杂志》2003年第9期925-927,共3页China Journal of Cancer Prevention and Treatment

摘　　要：目的 :研究原发性肺癌患者外周血内皮抑素 (endostatin)的含量水平与肺癌临床病理因素的关系。方法 :用ELISA法对 79例原发性肺癌、8例肺部良性疾病及 2 0例健康人血浆内皮抑素含量进行分析。结果 :血浆内皮抑素含量在原发性肺癌、肺部良性疾病及健康人分别为 (9 3± 5 7)pg mL、(6 3±2 5 )pg mL、(4 9± 3 2 )pg mL ,肺癌明显高于肺部良性疾病和健康人 ,P <0 0 5 ;血浆内皮抑素含量在Ⅰ、Ⅱ、Ⅲ、Ⅳ期肺癌中分别为 (6 6± 4 3)pg mL、(7 1± 5 5 )pg mL、(8 7± 6 0 )pg mL、(10 6± 4 5 )pg mL ,血浆内皮抑素含量与肺癌临床分期有关 ,P <0 0 5 ;年龄≥ 6 0岁肺癌患者血浆内皮抑素含量为 (7 9± 4 2 )pg mL ,年龄 <6 0岁为 (10 4± 5 6 )pg mL ,后者明显高于前者 ,P <0 0 1。结论 :原发性肺癌患者外周血内皮抑素含量水平显著高于正常对照 。Objective To evaluate the clinical significance of serum endostatin levels in the patients with primary lung cancer.Methods Serum endostatin concentrations were measured by enzyme linked immunocorbant assay in healthy persons and 79 lung cancer patients before surgery.The association between serum endostatin levels and clinicopathological features was analyzed.Results Serum endostatin levels in pulmonary carcinoma patients were significantly higher than those in healthy person.There was a significant association between serum endostatin levels and the disease stage,and the presence of lymph node metastases.Conclusion Serum endostatin levels in lung cancer patients are significantly higher compared with normal controls and correlated with the disease stage and the presence of lymph node metastases.

关 键 词：肺肿瘤/病理学 肺肿瘤/血液 血浆内皮抑素 

分 类 号：R734.2[医药卫生—肿瘤]