大鼠种植型肝癌电化学治疗与射频治疗的疗效比较  

Comparison of therapeutic effects of electrochemotherapy and radiofrequency ablation on rats with implanted liver cancer

作　　者：邵成伟[1] 王培军[1] 田建明[1] 张火俊[1] 左长京[1] 郝西彦[1] 任方远[1] 袁庆中[1] 李树平[1] 

机构地区：[1]第二军医大学长海医院放射科,上海200433

出　　处：《介入放射学杂志》2003年第2期126-128,共3页Journal of Interventional Radiology

基　　金：国家自然科学基金 (3 0 0 70 2 3 3 )

摘　　要：目的　比较电化学疗法与射频治疗对大鼠种植型肝癌的治疗效果。方法　制作大鼠肝癌动物模型 ,分别应用电化学疗法与射频疗法进行治疗 ,1周后影像学、病理光镜观察肿瘤大小、坏死、凋亡变化 ,与荷瘤对照组比较 ,并观察生存期的长短。结果　治疗前 ,所有大鼠肝肿瘤平均体积为 (10 0±6 )mm3 ,治疗后 1周 ,电化学治疗组大鼠肝肿瘤平均体积为 (12 5± 10 )mm3 ,射频治疗组大鼠肝肿瘤平均体积为 (14 3± 12 )mm3 ,而荷瘤对照组肝肿瘤平均体积为 (190± 11)mm3 ;两治疗组间比较差异无显著性 ,与对照组比较差异有显著性P <0 .0 5。两治疗组组织病理检查 ,光镜下均见肿瘤组织坏死明显 ,并可诱发细胞凋亡 ;生存期明显延长。结论　电化学疗法与射频治疗均可明显促进肿瘤坏死 ,诱发细胞凋亡 ,抑制肿瘤生长 。Objective To compare the therapeutic effects of electrochemotherapy (EChT) and radiofrequence ablation (RFA) on rats with implanted liver cancer.Methods Immediate cancerous ascites injection method was utilized for creation of rats liver cancer model and followed by treatment with EchT and RFA respectively. Tumor size, necrosis and apoptosis were observed one week later by imaging and pathology. The results were compared with those of control group. The survival times were observed also. Results Before treatment, all rats average liver tumor volume was (100±6)mm 3. One week after treatment, average tumor volumes in EChT group [(125±10)mm 3] and RFA group [(143±12)mm 3] were significantly smaller than those of control group [(190±11)mm 3], but tumor volume showed significant statistical difference between EChT group and RFA group. Necrosis, apoptosis and survival times in EChT group and RFA group were significantly higher than those of control group.Conclusions EChT or RFA could promote tumor necrosis, induce apoptosis, inhibit tumor growth and prolong the survival time of rats with implanted liver cancer.

关 键 词：大鼠 种植型肝癌 电化学治疗 射频治疗 疗效 细胞凋亡 

分 类 号：R735.7[医药卫生—肿瘤] R730.56[医药卫生—临床医学]