大鼠种植型肝癌电化学治疗后影像学特征的改变  

Imaging feature changes of rats with implanted liver cancer after electrochemotherapy

作　　者：邵成伟[1] 王培军[1] 田建明[1] 张火俊[1] 左长京[1] 郝西彦[1] 任方远[1] 袁庆中[1] 李树平[1] 

机构地区：[1]第二军医大学长海医院放射科,上海200433

出　　处：《介入放射学杂志》2003年第2期132-134,共3页Journal of Interventional Radiology

基　　金：国家自然科学基金资助 (3 0 0 70 2 3 3 )

摘　　要：目的　了解大鼠种植型肝癌电化学治疗前后的影像学特征变化。方法　采用直接注射法制作大鼠肝癌动物模型 ,应用CT、MRI观察大鼠种植型肝癌电化学治疗前后肿瘤大小、密度、边缘、强化、信号等影像学特征变化。结果　大鼠肝癌种植后 7d ,种植肝叶均可见类圆形、单发瘤灶影 ,大小约0 .6～ 0 .8cm ,CT平扫为低密度 ,增强后边缘强化 ;MRI扫描T1WI为低信号 ,T2 WI为高信号。电化学治疗后 7d ,CT平扫均为低密度 ,增强后无明显强化 ;MRI扫描T1WI为高信号为主混杂信号 ,T2 WI为相对低信号。Objective To study the changes of imaging features of rats with implanted liver cancer before and after electrochemotherapy (EChT).Methods Immediate cancerous ascites injection method was used to form rats liver cancer model. The imaging features of rats with implanted liver cancer, including tumor size, density, border, enhancement and singal were observed with CT and MRI respectively. Results The characteristic magings showed all these rats bearing single, round tumor in liver seven days later. Low density lesions were seen in pre contrast scans and tumor border intensification were seen on contrast scans. Low signal lesions were found in MRI T 1WI and high signal lesions were revealed on MRI T 2WI. Seven days after EchT, low density lesions were seen in pre contrast scan and non enhanced appearences were seen in contrast scan by CT. High signal and mixed signal lesion were seen in MRI T 1WI and relative low signal lesion were seen in MRI T 2WI.Conclusions Imaging features analysis is useful to assess the therapeutic effect on rats with implanted liver cancer before and after EChT.

关 键 词：大鼠 种植型肝癌 电化学治疗 影像学特征 细胞增殖 作用机制 

分 类 号：R735.7[医药卫生—肿瘤] R730.56[医药卫生—临床医学]