E-钙粘素、组织金属蛋白酶抑制剂2的表达与大肠癌临床病理因素的关系  

Relationship of expression of E-cadherin and tissue inhibitor of metalloproteinase-2 to clinical and pathologic factors of colorectal cancer

作　　者：陶雅军[1] 温冬青[1] 赵彩虹[1] 裘红梅[1] 苗迎秋[1] 

机构地区：[1]大连大学医学院基础I教研室,大连116622

出　　处：《中国免疫学杂志》2004年第2期106-107,110,共3页Chinese Journal of Immunology

摘　　要：目的 :探讨E 钙粘素 (E Cad)、组织金属蛋白酶抑制剂 2 (TIMP 2 )表达与大肠癌临床病理因素的关系。方法 :采用S P免疫组织化学染色技术 ,检测 30例大肠腺瘤 ,6 0例大肠癌组织E Cad和TIMP 2的表达情况。结果 :E Cad的表达率在大肠腺瘤中为 87 10 % ,显著高于大肠癌中的 5 5 0 0 % (P<0 0 5 ) ;其表达与大肠癌的大体类型有关 ,且随着大肠癌分化程度的降低而减少 ,与淋巴结转移呈负相关 (P均 <0 0 5 ) ,但E Cad的表达与大肠癌患者的生存期无明显相关性 (P >0 0 5 )。TIMP 2的表达在大肠腺瘤和大肠癌组织中没有显著性差异 (P >0 0 5 ) ;但其表达与大肠癌的Dukes分期、淋巴结转移、远隔脏器转移及生存期均有关 (P均 <0 0 5 )。结论 :E Cad和TIMP 2的检测可以成为临床判断大肠癌的恶性程度及转移的重要参考指标 ,而且TIMP 2的检测可用来判断大肠癌患者的预后。Objective:To investigate the role of the expression of E-cadherin(E-Cad) and tissue inhibitor of metalloproteinases-2(TIMP-2) in carcinogenesis and progression of colorectal cancer(CRC).Methods:The E-Cad and TIMP-2 expressions were studied immun ohistochemistrically in 30 specimens of colorectal adenoma and 60 specimens of CRC.Results:The expression rates of E-Cad were 87.10% in colorectal adenoma and 55.00% in CRC, the former was apparently higher than that of the later (P<0.05);The significant relationship was observed between low E-Cad expression and growth style and cellular differentiation and negative correlation to metastasis of lymph node. No apparent correlation was observed between the expressions of TIMP-2 and colorectal adenoma and CRC (P>0.05);The significant relationship was observed between low TIMP-2 expression and Dukes stage, metastasis of lymph node and distant organs and poor prognosis.Conclusion:The detection of expression about E-Cad and TIMP-2 may be helpful to judge the malignant behavior and metastasis and prognosis with colorectal carcinoma,furthermore the expression of TIMP-2 may be used to know prognosis of patients.

关 键 词：E-钙粘素 组织金属蛋白酶抑制剂-2 大肠癌 

分 类 号：R735.3[医药卫生—肿瘤]