PDGFR及c-Fos的表达与膀胱癌临床生物学特征的关系  

Association of the expressions of platelet-derived growth factor receptor and c-Fos with the biological characteristics of bladder cancer

作　　者：姚华强[1] 彭瑛[2] 钟世镇[1] 何恢绪[3] 李忠华[1] 

机构地区：[1]第一军医大学临床解剖研究所,广东广州510515 [2]广州军区联勤部东皋干休所,广东广州510055 [3]广州军区总医院泌尿外科,广东广州510010

出　　处：《第一军医大学学报》2004年第2期177-179,183,共4页Journal of First Military Medical University

基　　金：广东省科技计划项目(A302020401)~~

摘　　要：目的探讨膀胱移行上皮细胞癌(BTCC)组织中血小板源性生长因子受体(PDGFR)及癌蛋白c-Fos(c-Fos)的表达与BTCC的关系。方法应用免疫组化SP法检测43例BTCC组织、11例正常膀胱组织、14例癌旁组织中PDGFR及c-Fos的表达。结果PDGFR表达于胞膜、核膜和胞质;c-Fos表达于胞核和胞质。PDGFR和c-Fos在BTCC组织表达阳性率均显著高于正常和癌旁组织(P<0.05);两者在BTCC血管中的染色明显深于正常血管。c-Fos的表达在BTCC的分级中存在显著性差异(P<0.05)。结论PDGFR和c-Fos的表达可调控膀胱的多种组织,过度表达与BTCC的发生密切相关,并可能与肿瘤的血管形成相关。c-Fos的表达可反映BTCC细胞的增殖状态。Objective To elucidate the relation of platelet-derived growth factor receptor (PDGFR) and c-Fos protein expressions with human bladder transitional epithelial cell carcinoma (BTCC). Methods The expressions of PDGFR and c-Fos were investigated in 11 normal bladder tissue samples, 14 adjacent non-carcinoma tissues and 43 BTCC tissues by means of SP immunohistochemical technique. Results The c-Fos expression was found in the cell nuclei and cytoplasm, and PDGFR in the nuclear membrane, cytoplasm, and cellular membrane. PDGFR and c-Fos were detected in 81.40% and 48.83% of the BTCC tissues respectively, at the rates both significantly higher than those in normal and adjacent non-carcinoma tissues (P<0.05). Correlation between the expression of c-Fos and the tumor grading was noted (P<0.05). The expressions of PDGFR and c-Fos in tumor blood vessels were significantly higher than those in normal vessels. Conclusions The expressions of PDGFR and c-Fos might be involved in the development of BTCC, possibly related to the angiogenesis of the tumors. c-Fos expression can indicated the cell proliferative status of the BTCC.

关 键 词：PDGFR C-FOS 基因表达 生物学特征 血小板源性生长因子受体 膀胱移行上皮细胞癌 

分 类 号：R737.14[医药卫生—肿瘤]