紫苏油对衰老小鼠脑组织GSH含量的影响  

Effect of perilla oil on GSH content of the brain in SSA-mice induced by D -galactose

作　　者：霍天瑶[1] 金安娜[2] 陈轶玉[2] 丁晶晶[1] 黄成[1] 

机构地区：[1]南京大学生物科学与技术系,南京市汉口路22号210093 [2]江苏职工医科大学,南京市210029

出　　处：《中国油脂》2004年第2期68-70,共3页China Oils and Fats

基　　金：南京大学与江苏职工医科大学"α -亚麻酸药理作用研究"合作项目

摘　　要：为了观察紫苏油对衰老小鼠脑组织中GSH含量的影响,实验对D-半乳糖导致的亚急性衰老小鼠每日灌胃不同剂量紫苏油,在人工饲养21、42、63d后,分别检测小鼠脑组织的GSH含量,并分别建立了GSH含量随剂量(C)变化的函数,求出各时间组的最低康复剂量、最佳有效剂量和最大极限剂量。结果显示,D-半乳糖能导致小鼠的GSH含量明显下降,紫苏油能提高GSH含量,且最低康复剂量、最佳有效剂量和最大极限剂量随着灌胃紫苏油时间的增加均有减小的趋势。但随着紫苏油剂量的提高,GSH含量先升后降。过量紫苏油的摄入反而增加了机体对抗氧化分子的消耗。To observe the effect of perilla oil on GSH content of the brain in subacute senescence-accelerated mice(SSA-mice)induced by D -Galactose, the mice were fed with different dosages of perilla oil everyday. After the usual rear for 21?42?63 days, GSH content of the brain in mice was assayed, and the functions between the GSH values (GSH) and the dosage of perilla oil(C ) were formed with statistical methods. The conclusion is that D -galactose is able to reduce the GSH content of the brain in SSA-mice,while perilla oil can improve it, and the lowest cure dosage,the best dosage and the largest cure dosage of the oil all tend to decrease with the time of feeding it. With the dosage increase of perilla oil,the GSH content increases first, while decreases after that.

关 键 词：紫苏油 脑组织 GSH含量 抗衰老 药用 动物实验 

分 类 号：R285.5[医药卫生—中药学]