中国人群雄激素受体基因CAG多态性与前列腺癌关系的研究  

The relationship between CAG polymorphisms of androgen receptor gene and prostate cancer in Chinese patients

作　　者：李鸿伟[1] 刘建河[1] 王军起[1] 古力米热 席志军[1] 李鸣[1] 俞莉章[1] 那彦群[1] 

机构地区：[1]北京大学第一医院泌尿外科北京大学泌尿外科研究所,100034 [2]新疆乌鲁木齐市友谊医院

出　　处：《中华泌尿外科杂志》2004年第2期81-83,共3页Chinese Journal of Urology

基　　金：国家自然科学基金资助项目 ( 30 0 70 755)

摘　　要：目的　探讨国人雄激素受体 (AR)基因CAG多态性分布及与前列腺癌的关系。　方法　采用PCR、DHPLC和直接测序方法 ,对 10 5例前列腺癌和 190例健康老年男性外周血标本进行AR基因CAG重复长度测定 ,分析评价CAG重复长度与前列腺癌易感性的关系。　结果　前列腺癌和对照组ARCAG平均重复长度分别为 2 2 .7和 2 3 .3 ,差异无显著性意义 (P =0 .2 2 )。CAG重复长度<2 2与≥ 2 2相比 ,患前列腺癌的危险性增加 2 .3 9倍 ,差异有显著性意义 (P =0 .0 12 )。　结论　中国男性人群AR基因短的CAG重复长度 (<2 2 )与前列腺癌的危险性有关。与西方人群研究结果相比 。Objective To explore the distributions of C AG polymorphisms of androgen receptor gene in Chinese population and the relatio nship with prostate cancer (CaP). Methods The number of CAG repeats were measured in 105 cases with CaP and 190 matched case-control b y PCR、DHPLC and Sequencing analysis,and its association with the susceptibility to CaP. Results The average number of CAG repeats was 2 2.7 in CaP and 23.3 in control group ( P =0.22).Men with CAG repeats lengt h less than 22 may be in high risk of prostate cancer (odds ratio,2.39;95%CI 1.1 9～4.81, P =0.012),compared with men CAG repeats length of 22 or more. Conclusions A less CAG repeat length (<22) confers a higher ri sk of clinically significant prostate cancer in Chinese population.Compared with western men,our study subjects Chinese men had a more CAG repeat length.

关 键 词：中国人 雄激素受体基因 CAG多态性 前列腺癌 

分 类 号：R737.25[医药卫生—肿瘤]