骨髓增生异常综合征49例实验室指标分析  

Analysis of Dysmyelopoiesis in 49 Patients with Myelodysplastic Syndrome (MDS)

作　　者：唐建发[1] 赵燕力[1] 王晓[1] 王丽虹[1] 霍岩岩[1] 田小平[1] 

机构地区：[1]河北医科大学第四医院血液室,石家庄050011

出　　处：《临床肿瘤学杂志》2004年第1期32-34,共3页Chinese Clinical Oncology

摘　　要：目的 :观察MDS骨髓细胞形态学病态改变血特点。方法 :对 4 9例MDS的骨髓涂片及血片 ,应用瑞氏—姬姆萨混合染液染色 ,进行骨髓及外周血细胞学分析。结果 :粒、红、巨核三系都有不同程度的病态造血。粒系主要以细胞核浆发育不平衡、内外浆、中性粒细胞核分叶不能或pelger Huet样畸形。红系以双核、花瓣核、碎核及巨幼样变为主。结论 :MDS患者以中老年居多 ,三系均有不同程度的病态改变 。Objective:To study the morphologic abnormalities and its characters in bone marrow (BM) cells in MDS patients.Methods:Morphologic changes in peripheral blood and BM cells were investigated with Wright-Giemsa staining. Results:Dysmyelopoiesis of various degrees was found in all patients, including dyserythropoiesis, dysgranulomonopoiesis and dysmegakaryocytopoiesis. The dysgranulopoietic features were mainly characterized with nuclear-cytoplasmic dissociation of maturation and hyposegmentation of the nucleus (pseudo-Pelger-Huet anomaly), while erythrocytes exhibited megaloblastoid maturation, nuclear lobulation, flower-like nucleus and karyorrhexis.Conclusion:There are trilineage dysplasia of different degrees in MDS, which chiefly affected middle-and old-aged people and presente with RA subtype most frequently.

关 键 词：骨髓增生异常综合征 细胞学 MDS 病例资料 血液科 

分 类 号：R739.42[医药卫生—肿瘤]