浓缩鱼油对高脂血患者血脂和血小板聚集及体外血栓形成的影响  

EFFECT OF FISH OIL CONCENTRATE ON SERUM LIPIDS, PLATELET AGGREGATION, AND IN VITRO THROMBOSIS

作　　者：刘玉军[1] 孙明堂[1] 黄元伟[2] 陈天秩[2] 夏舜英[3] 石津生[4] 

机构地区：[1]卫生学环境医学研究所 [2]浙江医科大学附属一院 [3]浙江医科大学附属二院 [4]解放军空军总医院

出　　处：《营养学报》1992年第1期17-22,共6页Acta Nutrimenta Sinica

摘　　要：本文报导204例高脂血患者服用富含二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)浓缩鱼油对血脂和载脂蛋白水平、血小板聚集率及体外血栓形成的影响。受试者每人每日服浓缩鱼油胶丸18粒(相当摄入EPA+DHA 3.7g),连服10周。试验期间受试者的生活与饮食习惯与试验前一致,禁服降脂药和血小板聚集抑制药。结果表明:血清甘油三酯(TG)、总胆固醇(TC)、载脂蛋白(apo)B水平及血小板聚集率均显著降低,血清高密度脂蛋白胆固醇(HDL-C)水平明显升高;体外血栓形成的血栓长度和湿或干重均显著减小;高血压患者的收缩压和舒张压亦较前明显降低;服后血浆脂肪酸含量变化显著,可诱导血小板聚集的花生四烯酸(AA,C20∶4,φ6)含量显著降低,而具有降血脂、抑制血小板聚集和扩血管作用的EPA和DHA含量成倍升高。The effect of fish oil concentrate, rich in eicosapentaenoate (EPA) and docosahexaenoate (DHA), on serum lipids, platelet aggregation, in vitro thrombosis, and plasma fatty acid composition was investigated in 204 hyperlipidemic subjects. The subjects were given 6 capsules, weighing 280mg and comprising 25% EPA, 50% DHA, and 1.0% α-tocopherol percapsule, with each meal (3 times a day) for 10 weeks. The intake of EPA and DHA was 3.7g daily.The results showed that the serum triglyce-ride, total cholesterol, and apoprotein B levels were significantly decreased but high density lipoprotein cholesterol (HDL-C) was significantly increased. A significant decrease in ADP-induced platelet aggregation at 5 to 10 weeks after EPA + DHA treatment, was observed together with an increase in the plasma ratio of EPA to arachidonic acid. In vitro thrombosis was markedly inhibited at 10 weeks after treatment. In twenty-one hypertensive subjects, their systolic and diastolic blood pressure were markedly lowered at the end of the period.

关 键 词：农缩 鱼油 血脂 血小板 血栓形成 

分 类 号：R589.202[医药卫生—内分泌]