急性出血性脑血管病脑脊液中sICAM-1含量分析  

The Content Change of sICAM-1 in Fluid of Cerebrospinal Acute Cerebral Vessels Hemorrhage Disease

作　　者：李介华[1] 徐国祥[1] 冯建容[1] 徐辉[1] 

机构地区：[1]广东省清远市暨南大学医学院第五附属医院暨清远市人民医院,511500

出　　处：《中西医结合心脑血管病杂志》2004年第2期81-82,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省医学科研基金项目 (No .A2 0 0 0 80 8);清远市医学科研计划资助项目 (No.2 0 0 0 1 3)

摘　　要：目的　观察脑出血、蛛网膜下腔出血后脑脊液中可溶性细胞间黏附分子 -1 (sICAM -1 )的变化。方法　采用酶联免疫吸附试验检测脑出血、蛛网膜下腔出血后脑脊液中sICAM -1的含量。结果　正常人脑脊液中sICAM -1含量低微 ,而脑出血、蛛网膜下腔出血病人脑脊液中sICAM -1含量显著升高(P <0 .0 1 ) ,动态观察表明脑出血第 1天已达高峰 ,第 3天后开始下降 ,但仍维持在较高水平。结论　脑脊液中sICAM -1含量显著升高可反映脑组织损伤后的炎性反应程度 ,脑出血后第 1天脑组织局部的炎症应激反应明显加强。Objective To observe the content change of soluble intercellular adhesion molecule-1(slcAM-1) in cerebrospinal fluid of the patients suffered cerebral hemorrhage and subarachnoid hemorrhage.Methods The sLCAM-1 content in the patient's cerebrospinal fluid was determined by enzyme linked immunosorbent assay(ELISA).Results The sLCAM-1 content was a few in the normal man ,but it was dramatic rise in the patients (P<0.01). Dynamic observation could know that the content was high peak on the first day and it began to drop on the third day ,but it still kept higher level.Conclusions The high level of sLCAM-1 reflected brain inflammatory reaction degree and it was obvious strengthen after cerebral hemorrhage.

关 键 词：急性出血性脑血管病 脑脊液 SICAM-1 含量检测 可溶性细胞间黏附分子-1 

分 类 号：R743.34[医药卫生—神经病学与精神病学] R446.14[医药卫生—临床医学]