原发性肺癌患者外周血内皮抑素检测的临床意义  

SERUM ENDOSTATIN LEVELS IN PATIENTS WITH PRIMARY LUNG CANCER

作　　者：石殿鹏[1] 王颖[2] 于金明[3] 李道堂[1] 郭其森[4] 

机构地区：[1]山东省肿瘤医院胸外科 [2]山东省医学科学院附属医院检验科,山东济南250062 [3]山东省肿瘤医院放疗科,山东济南250117 [4]山东省肿瘤医院化疗科,山东济南250117

出　　处：《肿瘤研究与临床》2004年第1期22-23,共2页Cancer Research and Clinic

摘　　要：目的:研究原发性肺癌患者外周血内皮抑素的含量水平与肺癌临床病理因素的关系。方法:用ELISA法对79 例原发性肺癌、8 例肺部良性疾病及20 例健康人血浆内皮抑素含量进行分析。结果:血浆内皮抑素含量肺癌组明显高于肺部良性疾病和健康人,差异具有显著性(P<0.05);血浆内皮抑素含量与肺癌临床分期有关(P<0.05);年龄≥60 岁肺癌患者血浆内皮抑素含量明显高于年龄<60 岁肺癌患者,且差异有显著性(P<0.01)。结论:原发性肺癌患者外周血内皮抑素含量水平显著高于正常对照,且含量与肿瘤分期有关。Objective:To elevate the clinical usefulness of serum endostatin levels in patients with operable lung cancer.Methods:Serum endostatin concentrations were measured by an enzyme linked im-munosorbent assay in healthy controls and in79lung cancer patients before surgery.The association be-tween serum endostatin levels and clinicopathological features was observed.Results:Serum endostatin lev-els in pulmonary carcinoma patients were significantly higher than those in controls.There was a significant association between serum endostatin levels and disease stage,and the presence of lymph node metastases.Conclusion:Serum endostatin levels in lung cancer patients are significantly higher compared with normal controls and correlate with disease stage.

关 键 词：肺癌 血浆内皮抑素 临床病理特征 

分 类 号：R734.2[医药卫生—肿瘤]