缝-脊5-羟色胺痛调制系统的形态学鉴定  

ULTRASTRUCTURE IDENTIFICATION OF RAPHE-SPINAL SEROTONERGIC PAIN MODULAT ING SYSTEM IN RATS

作　　者：李戬[1] 侯颖一[2] 谭金山[2] 

机构地区：[1]济宁医学院解剖教研室,山东272113 [2]青岛医学院电镜室,山东266012

出　　处：《针刺研究》1992年第3期191-195,共5页Acupuncture Research

摘　　要：在内源性痛调制系统中,中缝大核(NRM)及邻近结构的神经元轴突行向脊髓后角,其释放的5-羟色胺(5-HT)可能对后角内痛敏神经元。5,6-dihydroxytryptamine was microinjected into the nucleus raphe magus (NRM)of rate. The sections of upper cervical segments were processed for immunoreaclive substance P (SP). The degenerated axon terminals and immunoreactive fibers were identified by electron microscopy. The results show that the degenerated axon terminals and immunoreactive positive dendrites and axons were found in the laminae I and II of the dorsal horn. The electron-dense axon terminals were in contact with unlabelled dendrites, some also in contract with immunoreactive dendrites. In lamina II, one of degenerated axon terminals as a center was contacted by several unlabellcd axonal boutons. SP labelled terminals were synapsed with unlabelled dendrites and dendritic spinej in addition, unlabelled axo-axonal synapse was found in lamina II. These results suggest that 5-HT axon terminals from NRM directly innervate SP and non-SP neurons in the laminae I and II.

关 键 词：血清素 痛调制系统 形态学 

分 类 号：R224.2[医药卫生—中医基础理论]