激光联用环磷酰胺对荷瘤鼠外周血IgG影响的实验研究  

Study on the Effects of He-Ne Laser Irradiation Combined with Cyclophosphamide on Peripheral Blood Serum IgG in Mice Inoculated with S180 Ascites Sarcoma

作　　者：黄保续[1] 王洪斌[1] 刘焕奇[1] 曲志娜[2] 刘西锋[1] 程绍辉[1] 高利[1] 

机构地区：[1]东北农业大学动物医学院,黑龙江哈尔滨150030 [2]农业部动物检疫所,山东青岛266032

出　　处：《中国激光》2004年第3期377-380,共4页Chinese Journal of Lasers

基　　金：国家自然科学基金 (项目批准号 :30 170 712 )资助项目

摘　　要：以小鼠S180腹水瘤为动物实验模型 ,对氦氖激光照射与化疗药物环磷酰胺 (CYT)联合应用对S180荷瘤鼠外周血IgG含量影响作了系统性研究。应用 11 0 0 ,14 6 7和 2 2 0 0J/cm2 三种剂量氦氖激光照射荷瘤鼠内眼角 ,同时联合应用化疗药物环磷酰胺 ,动态监测S180荷瘤鼠外周血IgG含量的变化。结果表明 。Systematic experiments on the effects of He-Ne laser irradiation combined with the traditional antitumor medicine of cyclophosphamide on peripheral blood serum IgG were conducted by using the experimental model of mouse S180 ascites sarcoma. Three groups of tumor bearing mice were irradiated upon the inner corners with the dosages of 11 00, 14 67 and 22 00 J/cm 2 He-Ne laser irradiation respectively, and injected with CYT intraperitoneally to observe the changes of peripheral blood serum IgG in tumor bearing mice. The values of peripheral blood serum IgG in tumor bearing mice in the mice with CYT+ He-Ne laser irradiation treatment were higher than that with CYT treatment only. The kinetic detection of peripheral blood serum IgG indicated that CYT showed the immunosuppressive effects on the tumor bearing mice, and the immunosuppressive effects were alleviated in some degree by He-Ne laser irradiation.

关 键 词：免疫病理学 氦氖激光照射 环磷酰胺 CYT 外周血IgG含量 小鼠 S180腹水瘤 荷瘤 

分 类 号：R730.5[医药卫生—肿瘤]