Objective To investigate the clinical characteristics and prognosis of cytomegalovirus-sepsis-like syndrome(CMV-SLS)in premature infants,and to provide the evidence for early clinical identification and treatment.Meth...
supported by the National High-Level Hospital Clinical Research Funding(No.BJ-2022-118);CAMS Innovation Fund for Medical Sciences(No.2021-1-I2M-050);National Natural Science Foundation of China(Nos.52273281 and 82173109);Guangxi Science and Technology Base and Talent Special Projects(No.AD21220001).
Background:One of the significant challenges for cell therapies,such as chimeric antigen receptor(CAR)-T cell therapy,is the poor infiltration of immune cells into tumor tissues.CAR-monocytes/macrophages(CAR-M)are pro...
Shandong Provincial Laboratory Project,Grant/Award Number:SYS202202;National Natural Science Foundation of China,Grant/Award Numbers:81972888,82272819;Research Project of Jinan Microecological Biomedicine Shandong Laboratory,Grant/Award Numbers:JNL-202219B,JNL-202204A,JNL-2023017D;Jiangsu Provincial Key Research and Development Program,Grant/Award Number:BE2022840;Nanjing University of Chinese Medicine,Grant/Award Number:2020YLXK007。
Phagocytosis,a vital defense mechanism,involves the recognition and elimination of foreign substances by cells.Phagocytes,such as neutrophils and macrophages,rapidly respond to invaders;macrophages are especially impo...
This work was supported by the grants from the General Program of the National Natural Science Foundation of China(No.82370005);the National Key Research and Development Program(No.2021YFC2302100);the Capital Health Development Scientific Research Unit Matching Fund(No.2020-2Z-2086);the Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support(No.XMLX202115);the National Capacity Building Project for Multidisciplinary Diagnosis and Treatment of Major Diseases(No.2019YLFW);the Beijing Key Clinical Specialty Project(No.2020ZDZK1);the National Key Research and Development Program(No.2020YFC2005404).
Cryptococcus gatti(Cg)is a facultative intracellular pathogen that can replicate and disseminate in mammalian macrophages,causing life-threatening cryptococcosis in both immunocompetent and immunocompromised in-dividu...
supported by the National Key Research and Development Program of China (No.2021YFA1101901);the Fundamental Research Funds for the Central Universities,HUST (No.2021GCRC073).
A small proportion of mononuclear diploid cardiomyocytes(MNDCMs),with regeneration potential,could persist in adult mammalian heart.However,the heterogeneity of MNDCMs and changes during development remains to be illu...
A rare case of occult cytomegalovirus(CMV)cholangitis along with an updated literature review is presented.The patient had not undergone solid organ-bone marrow transplantation and had no chronic autoimmune biliary tr...
Supported by the NIH(R01AG061034(AR),R35HL15531(AR),R21AG077040(HL),and K08HL140200(JR));the American Heart Association(20CDA35310184(HL)and 19AMFDP34990046(JSG));Sarnoff Cardiovascular Research Foundation Fellowship award(LET and CS);Massachusetts General Hospital Sanchez-Ferguson Faculty Scholar Program(JSG)。
Cardiomyocytes comprise~70%to 85%of the total volume of the adult mammalian heart but only about 25%to 35%of its total number of cells.Advances in single cell and single nuclei RNA sequencing have greatly facilitated ...