子宫颈及子宫内膜肿瘤组织EGFR和c-erbB-2的表达及其意义  

EXPRESSION OF EGFR AND c-erbB-2 IN UTERINE NEOPLASMS AND ITS SIGNIFICANCE

作　　者：姜天福[1] 魏志敏[1] 刘祖华[2] 孟云霄[1] 梁超群[1] 

机构地区：[1]青岛大学医学院附属医院病理科,山东青岛266003 [2]青岛市肿瘤医院病理科

出　　处：《青岛大学医学院学报》2004年第1期15-16,19,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的　观察子宫颈及子宫内膜肿瘤组织中表皮生长因子受体 (EGFR)和原癌基因c erbB 2的表达及其意义。②方法　采用免疫组化方法对 77例子宫颈和 72例子宫内膜正常及肿瘤组织进行EGFR和c erbB 2检测。③结果　c erbB 2在子宫颈鳞状细胞癌和子宫内膜腺癌组织中有较高的表达率 ,分别为 71 .1 %和 6 8.9%。子宫颈鳞状细胞癌c erbB 2阳性表达率与正常宫颈鳞状上皮及不典型增生比较有显著性差异 (χ2 =1 0 .31 3、5 .5 4 8,P<0 .0 5 ) ;子宫内膜腺癌c erbB 2阳性表达率与子宫增殖期内膜、分泌期内膜及子宫肌腺病组比较均有显著性差异(P =0 .0 0 1～ 0 .0 1 2 ) ;而EGFR在各组织内表达比较均无显著性差异 (χ2 =4 .2 4 0、0 .2 4 0 ,P >0 .0 5 )。④结论　c erbB 2是鉴别子宫颈和子宫内膜肿瘤良恶性和判断预后的一个有价值的指标。Objective To investigate the expression of epidermal growth factor receptor(EGFR) and c-erbB-2 oncogene protein in cervical and endometrial neoplasms. Methods 77 cases of cervical specimens and 72 cases of endometrial tissues were detected for EGFR and c-erbB-2. Results The positive rate of c-erbB-2 in cervical squamous cell carcinoma and in endometrial adenocarcinoma was 71.1% and 68.9% respectively. The c-erbB-2 expression rate in cervical squamous cell carcinoma was significantly higher than that in normal cervical tissue and CIN1 (χ 2=10.313, 5.548, P<0.05). The c-erbB-2 expression rate in endometrial adenocarcinoma was higher than that in proliferation and secretory phase and adenomyosis (P=0.001-0.012). The positive rates of EGFR in normal and neoplasm tissues showed no significant difference (χ 2=4.240, 0.240,P>0.05). Conclusion Detection of c-erbB-2 expression is valuable to determine the malignancy and prognosis of cervical squamous carcinoma and endometrial adenocarcinoma.

关 键 词：子宫颈 子宫内膜肿瘤 EGFR c—erbB-2 表达 肿瘤组织 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]