药物对大鼠根尖周组织中PGE_2作用及炎症影响探讨  

Effect of Various Intracanal Medications on PGE_2 and Inflammations of Periapicai Tissue

作　　者：杨卫东[1] 陈炯[2] 梁景平[2] 

机构地区：[1]南京市口腔医院口腔内科,江苏南京210008 [2]上海第二医科大学附属第九人民医院

出　　处：《口腔医学研究》2004年第2期165-168,共4页Journal of Oral Science Research

摘　　要：目的 :通过研究药物对根尖周组织中PGE2 作用及对根尖周组织炎症影响 ,探讨药物对根管治疗期间急性发作防治效果。方法 :以Wistar大鼠建立根尖周炎模型 ,根管预备后 ,分别在根管内置入红霉素、地塞米松、酮洛芬 ,术后 1d、3d、7d处死大鼠 ,放免检测根尖周组织中PGE2 含量 ,同时观察大鼠根尖周组织病理变化。结果 :根管预备后在根管内放置红霉素 ,根尖周组织炎症显著减轻 (P <0 .0 5 ) ,但根尖周组织中PGE2 含量无明显变化 (P >0 .0 5 )。根管内放置酮洛芬或地塞米松 ,根尖周组织中PGE2 含量显著降低 (P <0 .0 5 )。结论 :根管内放置红霉素可以抑制由炎症引起的根管治疗期间急性发作 ;放置酮洛芬或地塞米松可以显著抑制根尖组织中PGE2 的产生 。Objective: The aim of this study was to explore the etiological factor of endodontic flare-ups and to measure the effect of intracanal medications on endodontic flare-ups. Methods: This experimental model of periapical inflammation was established with Wistar rats. Erythomycine, Ketoprofen and Dexamethasone were placed in root canal of rats after instrumentation and the rats were killed on the first day, third day and seventh day after the operation. The level of prostaglandin E 2 of periapical tissue was measured by radio-immunity method. The degree of periapical inflammation of rats was also evaluated. Results:There was statistically significant difference between Erythomycine group and placebo group on inflammation level (P<0.05), and there was no statistically significant difference on the level of periapical prostaglandin E 2 (P>0.05). There was statistically significant difference between Ketoprofen or Dexamethasone group and placebo or Erythomycine group on the level of periapical prostaglandin E 2 (P<0.05). Conclusions: Erythomycine as the intracanal medication can not effectively reduce endodontic pain, but Erythomycine can significantly inhibit the periapical inflammation. Ketoprofen and Dexamethasone can both reduce postoperative pain by inhibiting periapical prostaglandin E 2. Dexamethasone also inhibit the periapical inflammation effectively.

关 键 词：根尖周组织 根尖周炎 急性发作 根管预备 组织病理学 PGE2 

分 类 号：R781.34[医药卫生—口腔医学]