乙二胺四乙酸铁钠强化酱油预防儿童贫血的效果观察  

Efficiency of NaFeEDTA fortified soy sauce on anemia prevention

作　　者：赵显峰[1] 卢启良 汪思顺 荫士安[1] 陈君石[1] 

机构地区：[1]中国疾病预防控制中心营养与食品安全所,北京100050 [2]贵州省毕节市卫生监督所 [3]贵州省卫生检验所

出　　处：《卫生研究》2004年第2期202-204,共3页Journal of Hygiene Research

摘　　要：目的　研究乙二胺四乙酸铁钠强化酱油预防缺铁性贫血高发地区儿童贫血的效果。方法　选择贵州省毕节市 9个村的儿童进行了为期 18个月的随机对照的双盲干预实验。在干预前和干预第 6、12和 18个月后分别测定了儿童末稍血血红蛋白含量 ,在干预前和干预 6个月后分别测量了儿童的身高、体重、上臂围和 3个部位的皮褶厚度。结果　强化组血红蛋白含量显著增高 [干预前 ( 111 0 8± 11 31)g L ,干预 12个月后 ( 12 2 99± 8 4 3)g L],贫血率显著下降 (干预前 5 8 0 % ,干预 12个月后 17 6 % ) ;干预 12个月后强化组儿童年龄别体重的增加值、三头肌和腹部皮褶厚度及其增加值显著高于对照组。结论　NaFeEDTA强化酱油可显著提高儿童血红蛋白水平 ,降低贫血患病率 ,促进儿童体重增长 ,增加皮下脂肪的积累。Objective Study the efficiency of the NaFeEDTA fortified soy sauce on anemia prevention among the children from iron deficiency anemia (IDA) prevalence region.Methods A double blind controlled random intervention in Bijie, Guizhou was conducted for 18 months. The finger hemoglobin (Hb) was detected at baseline and after 6, 12, 18 months intervention. Anthropometrics were also taken at baseline and after 12 months intervention. Results The Hb level increased significantly in the intervention group [(111 08±11 31)g/L at baseline and (122 99±8 43)g/L after 12 months], the anemia prevalence decreased markedly (58 0% at baseline, 17 6% after 12 months). After 12 months intervention, a significantly gain of the weight for age Z score (WAZ) was observed in the intervention group. The abdomen and triceps skin folders were thicker in the intervention group, and the intervention group had greater gains of the abdomen and triceps skin folders than those in the control group. Conclusion\ The soy sauce fortified with NaFeEDTA can increase the Hb level and decrease the prevalence of anemia in the children, and the NaFeEDTA fortified soy sauce can enhance the weight gain and the pull up of the subcutaneous fat. It is suggested that using NaFeEDTA fortified soy sauce in high IDA prevalence population was an efficient way for IDA preventing.

关 键 词：乙二胺四乙酸铁钠 儿童 贫血酱油 

分 类 号：R153.2[医药卫生—营养与食品卫生学] TS264.21[医药卫生—公共卫生与预防医学]