E-钙粘素和基质金属蛋白酶-2与大肠癌浸润转移的关系  

Relationship between the expression of E-cadherin,matrix metalloproteinase-2 and the invasion and metastasis of colorectal cancer

作　　者：陶雅军[1] 温冬青[1] 胡军[1] 宋光[1] 

机构地区：[1]大连大学医学院基础I教研室,大连116622

出　　处：《肿瘤》2004年第2期158-160,共3页Tumor

摘　　要：目的　探讨E 钙粘素 (E Cad)和基质金属蛋白酶 - 2 (MMP 2 )表达与大肠癌浸润转移的关系。　方法　采用S P免疫组织化学染色技术 ,检测 30例大肠腺瘤 ,6 0例大肠癌组织E Cad和MMP 2的表达情况。结果　E Cad的表达率在大肠腺瘤中为 87.10 ,显著高于大肠癌中的 5 5 .0 0 (P <0 .0 5 ) ;其表达随着大肠癌分化程度的降低而减少 ,与淋巴结转移及远隔脏器转移呈负相关 (P均 <0 .0 5 )。MMP 2的表达率在大肠腺瘤中为 2 6 .6 7 ,显著低于大肠癌中的 86 .6 7 (P <0 .0 5 ) ;其表达与年龄、大肠癌的大体类型、Dukes分期、分化程度、淋巴结转移和远隔脏器转移均密切相关 (P均 <0 .0 5 )。结论　E Cad和MMP 2的检测可以成为临床判断大肠癌的恶性程度、转移及预后的重要参考指标。Objective To investigate the role of the expression of E-cadherin(E-Cad) and matrix metalloproteinase-2 (MMP-2) in carcinogensis and progression of colorectal cancer(CRC). Methods The E-Cad and MMP-2 expressions were studied immunohistochemically in 30 specimens of colorectal adenoma and 60 specimens of CRC. Results The expression rates of E-Cad were 87.10﹪ in colorectal adenoma and 55.00﹪ in CRC( P <0.05). Significant relationship was observed between low E-Cad expression and cellular dedifferentiation but negative correlation to metastasis of lymph node and distant organs. The expression rate of MMP-2 was 26.67﹪ in colorectal adenoma significantly lower than the 86.67% in CRC( P <0.05). MMP-2 expression was closely related to cancer growth type,Dukes stage,cellular differentiation,and metastasis to lymph node and distant organs. Conclusion The detection of E-Cad and MMP-2 expression may be helpful to judge the malignant behavier,metastasis and prognosis of colorectal carcinoma.

关 键 词：E-钙粘素 基质金属蛋白酶-2 大肠癌 肿瘤浸润 肿瘤转移 预后 

分 类 号：R735.34[医药卫生—肿瘤]