溶媒萃取α-氧代-L-古龙酸的初步工艺研究  

PRELIMINARY STUDY OF SOLVENT EXTRACTION OF α-KETO-L-GULONIC ACID FROM FERMENTATION LIQUID

作　　者：钱卫国 沈金玉[1] 高春满[1] 沈忠耀[1] 

机构地区：[1]清华大学化学工程系

出　　处：《中国医药工业杂志》1992年第6期247-250,246,共5页Chinese Journal of Pharmaceuticals

摘　　要：为从发酵液中提取α-氧代-L-古龙酸(KGA),筛出较为合适的萃取剂、稀释剂、助萃剂和反萃剂。研究了 DOA 对 KGA 的萃取性能,以及 pH、无机酸和相比对萃取性能的影响。并对三级逆流萃取过程进行了串级模拟。实验结果表明,以溶剂萃取法从发酵液中提取 KGA 是可行的。Solvent extraction of a-keto-L-gulonic acid from the fermentationliquid was studied.If includes the selection of suitable extractants,diluents,co- extractants and strippants.The extraction be haviour of extractant DOA and theeffects of pH,inorganic acids and phase ratio on the extraction equilibrium weresystematically explored.The simulation test of 3 stages countercurrent extrac-tion was also done.The experimental results have shown that extraction of α-keto-L-gulonic acid from the fermentation liquid is feasible.

关 键 词：α-氧代 L-古龙酸 发酵液 溶剂萃取 

分 类 号：TQ460.6[化学工程—制药化工]