恒磁场对大鼠脑缺血—再灌注模型抗氧化能力的影响  

Effect of Constant Magnetic Field on Antioxidation Ability of Rats during Cerebral Ischemia-reperfusion

作　　者：许艳[1] 宋晓燕[1] 马波[1] 高佩琦[1] 

机构地区：[1]哈尔滨医科大学生物物理教研室,哈尔滨150086

出　　处：《中国血液流变学杂志》2004年第1期22-24,39,共4页Chinese Journal of Hemorheology

摘　　要：目的　研究恒磁场对脑缺血再灌注大鼠抗氧化能力的影响。方法　大脑中动脉线栓法建立脑缺血 90min再灌注模型 ,4 0mT恒磁场体外照射大鼠头部 30min/d ,共 7d ,测MDA、SOD(T SOD ,CuZu SOD ,Mn SOD)、GSH PX、T AO、CP的变化。结果　磁疗组中的MDA显著低于模型组 ,T SOD ,CuZu SOD ,T AO ,CP显著高于模型组 ,Mn SOD ,GSH PX相对模型组有增高趋势 ,但不显著。结论　恒磁场能在一定程度上提高大鼠脑缺血—再灌注模型的抗氧化能力。Objective To study the effect of constant magnetic field on antioxidation ability of rats during ischemia-reperfusion injury.Method The rats were given cerebral ischemia for 90 min by using suture method,then reperfused for 7 days. During the 7 days,rats in magnetic therapy group were exposed to 40mT constant magnetic field, then to measure the changes of MDA,SOD(T-SOD,CuZu-SOD, Mn-SOD),GSH-PX,T-AO and CP.Results MDA content in magnetic therapy group is significantly lower than that in model group.T-SOD,CuZu-SOD,CP activity and T-AO content in magnetic therapy group is significantly higher than that in model group,Mn-SOD,GSH-PX activity in magnetic therapy group is higher than that in model group,but not significantly.Conclusion To some extent,the constant magnetic field can increase the antioxidation ability of rats during cerebral ischemia-reperfusion injury.

关 键 词：恒磁场 大鼠 脑缺血-再灌注模型 抗氧化能力 脑血管疾病 

分 类 号：R743[医药卫生—神经病学与精神病学]