新型手性酪氨酸卟啉锌对咪唑类客体的分子识别研究  

Studies on Molecular Recognition of Imidazole Derivatives by Novel Chiral Tyrosine Tetraphenylporphinatozinc Complex

作　　者：王树军[1] 阮文娟[1] 赵小菁[1] 南晶[1] 朱志昂[1] 

机构地区：[1]南开大学化学系,天津300071

出　　处：《高等学校化学学报》2004年第5期908-912,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金(批准号 :2 0 1710 2 4;2 0 2 710 3 0 );天津市自然科学基金(批准号:0 2 3 60 40 11);教育部留学回国人员科研基金资助

摘　　要：合成了两种新型手性锌卟啉 Zn( o-Boc Tyr) TAPP和 Zn( p-Boc Tyr) TAPP.通过元素分析、紫外可见光谱及核磁共振谱对其性质进行了表征 .研究了这两种锌卟啉对咪唑类的分子识别行为 ,识别的缔合常数顺序均为 K( 2 -Me Im) >K( Im) >K( N-Me Im) >K( 2 -Et-4-Me Im) .同时 ,采用理论计算和圆二色谱研究了咪唑类小分子在与锌卟啉分子识别时进攻主体位置的变化 。Two kinds of novel chiral Zn porphyrin complexes were synthesized and characteried by means of elementary analysis, UV-Vis, 1H NMR. Molecular recognition was studied between hosts and imidazole derivatives. Association constants of Zn(o-BocTyr)TAPP and Zn(p-BocTyr)TAPP with imidazoles increased in the sequence K(2-MeIm>K(Im)>K(N-MeIm)>K(2-Et-4-MeIm). Through circular dichroism spectra and theoretical calculation method, the chang of position in which imidazoles coordinated to host 1 was studied, it is important to study the structral characterization of porphyrin.

关 键 词：手性锌卟啉 咪唑类衍生物 客体 手性分子识别 圆二色谱 分子力学 

分 类 号：O626.23[理学—有机化学] O641.3[理学—化学]