SRY调控性腺分化研究的进展  

Advances in Gonadal Differentiation Regulated by SRY

作　　者：崔英霞[1] 黄宇烽[1] 

机构地区：[1]南京军区南京总医院生殖遗传研究室,江苏南京210002

出　　处：《中华男科学杂志》2004年第5期323-326,共4页National Journal of Andrology

摘　　要：人类性腺的分化是由基因所决定的。在胚胎的未分化性腺分化为睾丸或卵巢时 ,性别就决定了。这个过程是一个复杂而精细的过程。位于Y染色体上SRY基因表达 ,引发了一个复杂的遗传过程 ,导致了睾丸的分化。然而 ,仅有少数 4 6 ,XY性反转的患者检出SRY基因的突变。其他参与性腺分化的基因有待发现。最近的研究工作表明 ,睾丸的分化受到胰岛素受体家族基因的调控 ,正常情况下SRY需通过两个不同的核运输途径使足够剂量的SRY蛋白进入细胞核调控性腺分化过程。Gondadal differentiation is genetically determined in humans. Sex is determined when the bipotential embryologic tissues differentiate into testes or ovary. SRY, a gene located on the Y chromosome, triggers a complex genetic cascade leading to testicular differentiation. However, only a minority of 46, XY sex reversal patients can be explained by SRY mutations, suggesting that other genes influencing sex deternimation are to be discovered. Recent studies show that testis differentiation requires insulin receptor family function in mice. SRY normally requires two distinct NLS-dependent nuclear import pathways to reach sufficient levels in the nucleus for gonadal differentiation.

关 键 词：SRY基因 性腺 性反转 IMPORTIN β 胰岛素受体家族 SOX9基因 

分 类 号：Q492[生物学—生理学]